@article{APS4119,
author = {Qin-zhao Yang and Huai-de Shu and Le-ru Lin},
title = {The blocking action of anabasin on the neuromuscular junction},
journal = {Acta Pharmacologica Sinica},
volume = {2},
number = {2},
year = {2016},
keywords = {},
abstract = {Anabsin, an alkaloid extracted from the root of Alangium chinense, exerted a significant neuromuscular blocking effect on isolated rat phrenic nerve-diaphragm preparations. This blocking action could be partly antagonized by neostigmine. On rat denervated diaphragms, anabasin inhibited the muscular response to acetylcholine.
Anabasin showed a depolarizing effect on isolated frog sartorius muscles. Anabasin (0.83 microg/ml) increased at first, and then decreased, the frequency of the miniature end-plate potentials (mepp). Anabasin inhibited the end-plate potential (epp) and its quantal content, but did not alter the nerve terminal potential (ntp).
In conclusion, anabasin has both presynaptic and postsynaptic effects on neuromuscular junction. It is a depolarizing muscle relaxant with some characteristics of competitive muscle relaxant.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4119}
}