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The blocking action of anabasin on the neuromuscular junction

	author = {Qin-zhao Yang and Huai-de Shu and Le-ru Lin},
	title = {The blocking action of anabasin on the neuromuscular junction},
	journal = {Acta Pharmacologica Sinica},
	volume = {2},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Anabsin, an alkaloid extracted from the root of Alangium chinense, exerted a significant neuromuscular blocking effect on isolated rat phrenic nerve-diaphragm preparations. This blocking action could be partly antagonized by neostigmine. On rat denervated diaphragms, anabasin inhibited the muscular response to acetylcholine.
Anabasin showed a depolarizing effect on isolated frog sartorius muscles. Anabasin (0.83 microg/ml) increased at first, and then decreased, the frequency of the miniature end-plate potentials (mepp). Anabasin inhibited the end-plate potential (epp) and its quantal content, but did not alter the nerve terminal potential (ntp).
In conclusion, anabasin has both presynaptic and postsynaptic effects on neuromuscular junction. It is a depolarizing muscle relaxant with some characteristics of competitive muscle relaxant.},
	issn = {1745-7254},	url = {}