TY - JOUR AU - Cheng You-lan AU - Ye Ju-rong AU - Lin Da-jie AU - Lin Lu-jie AU - Zhu Jun-ning PY - 2016 TI - Some toxicities of triptolide in mice and dogs JF - Acta Pharmacologica Sinica; Vol 2, No 1 (March 1981): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Triptolide is one of the antileukemic principles isolated from Trypterygium wilfordii. The acute LD50 of triptolide in mice=0.8 mg/kg iv and 0.9 mg/kg ip. Twelve dogs were given in 20, 40, 80 or 160 microg/kg daily for 7 days. The major target organs of toxicity were heart, liver and gitract. The lethal dose (160 microg/kg) depressed the hematopoietic system of bone marrow. Toxic doses low and toxic doses high were found to be 40 an 80 mirog/kg, respectively. The toxicities on heart, hematopoietic system and gi tract were reversible. No toxicity was found after 20 microg/kg. Delayed toxicity was absent in 6 weeks after withdrawal of triptolide. UR - http://www.chinaphar.com/article/view/4115