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Effects on animal tumors and toxicity of lycobetaine acetate

	author = {Su-yin Zhang and Fei-li Lu and Jin-long Yang and Long-jiang Wang and Bin Xu},
	title = {Effects on animal tumors and toxicity of lycobetaine acetate},
	journal = {Acta Pharmacologica Sinica},
	volume = {2},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Lycobetaine, a derivative of lycorine, is a new type of antitumor drug. When lycobetaine acetate (AT-1840) was given ip to mice and rats inoculated with Ehrlich ascites carcinoma, ascites hepatoma, leukemia L-1210, leukemia P-388, Lewis lung cardinoma or Yoshida ascites sarcoma, the survival times of the tumor-bearing animals were prolonged significantly. Lycorine exhibited only negligible effect on the above-mentioned tumors.
The acute ip LD50 of AT-1840 in mice was 72 mg/kg. In dogs iv 3 or 9 mg/kg of AT-1840 once every other day for 7 times produced no apparent toxic action except mild leucopenia and thrombopenia in the group of large dosage.
It seems that the presence of phenolic betaine in the molecule of AT-1840 bears some relationship to its antitumor activity.
AT-1840 has been recommended for clinical trials.},
	issn = {1745-7254},	url = {}