@article{APS4085,
author = {Kai-li Yue},
title = {Analgesic and antispastic effects of protopine},
journal = {Acta Pharmacologica Sinica},
volume = {2},
number = {1},
year = {2016},
keywords = {},
abstract = {The root of dactylicapnos scandens (D. Don) Hutchins, Fumariaceae, has been used as an anodyne in China. Protopine was isolated from the root. The analgesic and anti-spastic effects of protopine are reported in this paper.
The oral LD50 of protopine was 186+/-33 mg/kg in mice. Assayed with the stretching method, the median analgesic dose (ED50) in mice was 27+/-5 mg/kg. The electric stimulation experiment showed that the effect of protopine was weaker than that of morphine. Protopine could inhibit the contraction of duodenum of rabbits at the concentration of 1*10(-5) g/ml. It could antagonize the spasm of isolated ileum of rats induced by acetylcholine or BaCl2.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4085}
}