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Analgesic and antispastic effects of protopine

	author = {Kai-li Yue},
	title = {Analgesic and antispastic effects of protopine},
	journal = {Acta Pharmacologica Sinica},
	volume = {2},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {The root of dactylicapnos scandens (D. Don) Hutchins, Fumariaceae, has been used as an anodyne in China. Protopine was isolated from the root. The analgesic and anti-spastic effects of protopine are reported in this paper.
The oral LD50 of protopine was 186+/-33 mg/kg in mice. Assayed with the stretching method, the median analgesic dose (ED50) in mice was 27+/-5 mg/kg. The electric stimulation experiment showed that the effect of protopine was weaker than that of morphine. Protopine could inhibit the contraction of duodenum of rabbits at the concentration of 1*10(-5) g/ml. It could antagonize the spasm of isolated ileum of rats induced by acetylcholine or BaCl2.},
	issn = {1745-7254},	url = {}