How to cite item

Experimental therapy of filariasis with furapyrimidone

  
@article{APS4064,
	author = {Yu-rui Xi and Yuan-qing Yang and Hui-zhong Yang and Yu-xin Xu and Hui-fang Guo and Jin-hua Nie and He-xiang Liu},
	title = {Experimental therapy of filariasis with furapyrimidone},
	journal = {Acta Pharmacologica Sinica},
	volume = {1},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {It was found in animal tests that furapyrimidone, 1-[(5-nitrofurayl-2) methylene amino]tetrahyraopyrimidone-2-one, was an effective antifilarial agent. When cotton rats infected with Litomosoidescarinii were treated orally with furapyrimidone in the daily dose of 25 mg/kg for 5 consecutive days, all adult worms in the pleural cavity were killed. If the daily dose was increased to 100 mg/kg, the microfilariae in the peripheral blood were eradicated. When given orally to Mongolian jirds infected with Brugia malayi in the daily dose of 100-188 mg/kg for 5 consecutive days, part of the adult worms and a greater part of microfilariae in the peritoneal cavity as well as in the peripheral blood were killed. The LD50 in mice treated orally with a single dose of furapyrimidone was 243±31 mg/kg. When the drug was given to dogs at 25 or 75 mg/kg for 4-7 days, only the 75 mg/kg group exhibited some mild vomiting and a decrease of food intake. The histopathological lesions were of little importance.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4064}
}