TY - JOUR AU - Gu Hao-ming AU - Lv Bao-feng AU - Qu Zhi-xiang PY - 2016 TI - Antimalarial activities of 25 derivatives of artemisinine against chloroquine-resistant plasmodium berghei JF - Acta Pharmacologica Sinica; Vol 1, No 1 (September 1980): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - The antimalarial activities of 25 derivatives of artemisinine, including dihydroartemisinine, 13 ethers, 6 esters and 5 carbonates, were compared. Each compound, dissovlved in tea seed oil, was injected intramuscularly into mice infected with the chloroquine-resistant strain of Plasmodium berghei. Adopting SD90 as a comparision criterion, the results showed that many of the derivatives were much more potent than artemisinine. They are SM224(O-methyl dihydroartemisinine, beta) in the ethers, SM241 (butyryl dihydroartmisinine, alpha) and SM108 ( propionyl dihydroartmisinine, alpha) in the esters, and SM242(propoxy carbonyl dihydroartmisinine, alpha), SM275( ethoxy carbonyl dihydroartmisinine, alpha+beta), SM223 (ethoxy carbonyl dihydroartmisinine, alpha ) and SM 276 ( phenoxy carbonyl dihydroartmisinine, alpha+beta) in the carbonates. Their chemical structures and values of SD90 are presented in Table 1. UR - http://www.chinaphar.com/article/view/4062