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Distribution and excretion of 10-hydroxycamptothecin and its influence on immune response

	author = {Jin-long Yang and Jian-xian Han and Bin Xu},
	title = {Distribution and excretion of 10-hydroxycamptothecin and its influence on immune response},
	journal = {Acta Pharmacologica Sinica},
	volume = {1},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {3H-hydroxycamptothecin was injected into the tail vein of mice in a dose of 10 mg/kg. The decline of radioactivity in the blood showed a biphasic curve. The first biological half-life(t1/2alpha) was 4.5 min and the second(t1/2beta), 29 min. The highest radioactivites were found in the bile and intestinal contents, moderate in carcinoma cells, and lowest in bone marrow, thymus and spleen. The radioactivity was excreted mailly via feces. The excretion amounted to 30% within 24 h and 48% within 48 h. The radioactivity in urine in 48 h was 13% of the injected radioactivity. The influence of 10-hydroxycampatothecin on cell-mediated immune response  was investigated in mice bearing reticulum cell sarcoma with the method of concomitant 10-hydroxycamptothecin had a slight depressive action on immune response.In experiments of heterotransplantation of tumors, the immunosuppressive effect was also noticed. However, the degree of suppression depends upon the schedules of administration, among which the q 4 d schedule and the single large dose exhibited less inhibitory action. Such phenomenon appears to be related to the tissue distributions of the drug.},
	issn = {1745-7254},	url = {}