TY - JOUR AU - Tang Xi-can AU - Feng Jie AU - Wang Yue-e AU - Liu Ming-zhang PY - 2016 TI - Neuromuscular blocking activity of alkaloids of Cyclea hainanensis JF - Acta Pharmacologica Sinica; Vol 1, No 1 (September 1980): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - The neuromuscular blocking activity of 4’’-o-methyl-d-curine and dl-curine isolated from Cyclea hainanensis in Hai-nan Island were studied. It was found that the dimethyl dl-curine dimethochloride was 1-2.5 times more active than d-tubocurarine in conscious rabbits,cats and dogs,while 4’’-o-methyl-d-curine dimethiodide was less potent than d-tubocurarine.Dimethyl dl-curine dimethochloride. Dimethyl dl-curine dimethochloride and 4’’-o-methyl-d-curine dimethiodide had a non-depolarizing mode of action.In contrast to d-tubocurarine,its ganglion-blocking potency and histamine-releasing properties were weak. Hence the side effect of hypotension seen with d-tubocurarine was less severe than that with dimethyl dl-curine dimethochloride and 4’’-o-methyl-d-curine dimethiodide. In mice and rats dimethyl dl-curine dimethochloride and 4’’-o-methyl-d-curine dimethiodide exhibited a higher therapeutic index than d-tubocurarine. UR - http://www.chinaphar.com/article/view/3988