@article{APS3973,
author = {Kai Wang and Hua-hao Shen and Jun-chun Chen and Zhong Chen},
title = {Inhibitory effect of acetamide-45 on airway inflammation and phosphodiesterase 4 in allergic rats},
journal = {Acta Pharmacologica Sinica},
volume = {26},
number = {12},
year = {2016},
keywords = {},
abstract = {Aim: To determine the effects of acetamide-45 on respiratory function, airway inflammation, and the activity of phosphodiesterase 4 (PDE4) in allergic rats.
Methods: Rats were sensitized by a single intramuscular injection with ovalbumin (OVA) and were challenged with ovalbumin applied by using an aerosol repeatedly for 7 d after 2 weeks. Acetamide-45 at concentrations of 5, 10, or 30 mg/kg was then administered by intraperitoneal injection. Changes in dynamic lung compliance and lung resistance, the accumulation of inflammatory cells in bronchoalveolar lavage, PDE4 activity, and the concentration of interleukin-4 in rat lung tissue were determined.
Results: Seven days of treatment with acetamide-45 prevented eosinophil accumulation in allergic rats. At doses of 5, 10, and 30 mg/kg, acetamide-45 decreased lung resistance to 0.20plusminus0.04, 0.25plusminus0.07, and 0.22plusminus0.05 cmH2Odots-1dotmL-1, respectively (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3973}
}