@article{APS3964,
author = {Dong-soon Im},
title = {Two ligands for a GPCR, proton vs lysolipid},
journal = {Acta Pharmacologica Sinica},
volume = {26},
number = {12},
year = {2016},
keywords = {},
abstract = {Recently, two different chemicals have been matched as ligands with the same G-protein-coupled receptor (GPCR). Double-pairing of OGR1 family GPCRs with proton and lysolipid raises several questions. First, whether both are the real ligands for the GPCRs. Second, whether modulation of a GPCR by two chemicals could be possible. Third, one of the chemicals is proton. Proton-sensing not only is a new action mode of GPCR activation, but also it could be generalized in other GPCRs. In this review, I'd like to summarize the issue and discuss questions with pharmacological criteria.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3964}
}