@article{APS3864,
author = {Feng Qiu and Xiao-yan Chen and Bo Song and Da-fang Zhong and Chang-xiao Liu},
title = {Influence of dosage forms on pharmacokinetics of daidzein and its main metabolite daidzein- 7-O -glucuronide in rats},
journal = {Acta Pharmacologica Sinica},
volume = {26},
number = {9},
year = {2016},
keywords = {},
abstract = {Aim: To investigate the influence of dosage forms on the pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in Wistar rats.
Methods: After administration of two typical dosage forms (daidzein solution and suspension), the concentrations of daidzein and daidzein-7-O-glucuronide were determined by an LC-MS-MS method. The pharmacokinetic parameters were calculated and analyzed statistically using the Student's t-test.
Results: Absorption of daidzein after administration of daidzein solution (tmax= 0.46 h) was more rapid than that of the suspension (tmax= 5.00 h). The peak plasma concentrations of daidzein after administration of daidzein solution and suspension were 601.1 mug/L and 127.3 mug/L, respectively, and those of daidzein-7-O-glucuronide were 3000 mug/L and 192.6 mug/L, respectively. The absolute bioavailabilities of free daidzein in rats after administration of daidzein solution and suspension were 12.8% and 6.1%, respectively, which were calculated to be 47.0% and 12.2%, respectively, in the form of total daidzein (free plus conjugated daidzein).
Conclusion: Absorption of daidzein solution was better than absorption of suspension (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3864}
}