@article{APS3786,
author = {Jing-jing Sun and Lin Xie and Xiao-dong Liu},
title = {Transport of carbamazepine and drug interactions at blood-brain barrier},
journal = {Acta Pharmacologica Sinica},
volume = {27},
number = {2},
year = {2016},
keywords = {},
abstract = {Aim: To investigate the characteristics of carbamazepine (CBZ) transport and
drug interactions at the blood-brain barrier. Methods: Cultured rat brain microvascular
endothelial cells (rBMEC) were used as an in vitro model of the blood-brain
barrier (BBB). When cells became confluent, CBZ uptake over time was recorded
by incubation of the cells in a medium containing 10 mg/L CBZ at 37 ºC. The
steady-state uptake of CBZ by rBMEC was tested for different CBZ concentrations
at 37 ºC. The effects of various agents on the steady-state uptake of CBZ
and efflux of CBZ from rBMEC were also studied. Results: The uptake of CBZ by
rBMEC was time- and concentration-dependent. The steady-state uptake occurred
at 30 min for incubation. The steady-state uptake was significantly increased
(P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3786}
}