@article{APS3774,
author = {Song-tao Li and Xiao-wei Chen and Hong-mei Zhao and Na Li and Jie Yan and Zhi-an Hu},
title = {Effects of orexins on myoelectric activity of sphincter of Oddi in fasted rabbits},
journal = {Acta Pharmacologica Sinica},
volume = {27},
number = {2},
year = {2016},
keywords = {},
abstract = {Aim: To investigate the effects of peripheral orexins on myoelectric activity of the
sphincter of Oddi (SO) in fasted rabbits, and carry out a preliminary investigation
into the mechanisms underlying these effects. Methods: Myoelectric activity of
SO in fasted rabbits was recorded before and after intravenous or local application
of orexins. The effects of intravenous atropine on orexin-increased myoelectric
activity of SO were tested. Results: Myoelectric activity of SO was activated by
both intravenous and local injection of orexin-A or orexin-B. Intravenous application
of atropine completely inhibited the excitatory effect of orexins on SO.
Conclusion: Peripheral application of orexins can increase myoelectric activity of
SO in fasted rabbits, which is partially associated with the activation of the cholinergic
pathway.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3774}
}