@article{APS3764,
author = {Yan Fu and Chang-he Fan and He-huang Deng and San-hong Hu and De-peng Lv and Li-hua Li and Jun-jie Wang and Xin-qiao Lu},
title = {Association of CYP2D6 and CYP1A2 gene polymorphism with tardive dyskinesia in Chinese schizophrenic patients},
journal = {Acta Pharmacologica Sinica},
volume = {27},
number = {3},
year = {2016},
keywords = {},
abstract = {Aim: To investigate the possible association of the CYP2D6 gene C100T polymorphism and the CYP1A2 gene C163A polymorphism with tardive dyskinesia (TD) in Chinese patients with schizophrenia.
Methods: The recruited schizophrenic patients were assessed with the Abnormal Involuntary Movement Scale (AIMS), and divided into groups with TD (n=91) and without TD (n=91) according to the AIMS score. Polymorphisms of the CYP2D6 and CYP1A2 genes were determined by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP).
Results: No allele frequencies deviated from Hardy-Weinberg equilibrium. No significant differences in genotypes frequencies of the CYP2D6 C100T polymorphism were observed between patients with TD and without TD (χ2=4.078, P>0.05), but patients with TD had a significant excess of the T allele compared with those without TD (χ2=4.28, P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3764}
}