@article{APS3759,
author = {Lin Xiao and Yu-ming Wu and Hao Zhang and Yi-xian Liu and Rui-rong He},
title = {Hydrogen sulfide facilitates carotid sinus baroreflex in anesthetized rats},
journal = {Acta Pharmacologica Sinica},
volume = {27},
number = {3},
year = {2016},
keywords = {},
abstract = {Aim: To study effects of hydrogen sulfide (H2S) on the carotid sinus baroreflex (CSB).
Methods: The functional curve of the carotid sinus baroreflex was measured by recording changes in arterial pressure in anesthetized male rats with perfused carotid sinus.
Results: H2S (derived from sodium hydrosulfide) at concentrations of 25, 50, and 100 mol/L facilitated the CSB, shifting the functional curve of the baroreflex downward and to the left. There was a marked increase in peak slope (PS) and reflex decrease in blood pressure (RD). Effects were concentration-dependent. Pretreatment with glibenclamide (20 mol/L), a KATP channel blocker, abolished the above effects of H2S on CSB. Pretreatment with Bay K8644 (an agonist of calcium channels; 500 mol/L) eliminated the effect of H2S on CSB. An inhibitor of cystathionine -lyase (CSE), DL-propargylglycine (PPG; 200 mol/L), inhibited CSB in male rats and shifted the functional curve of the baroreflex upward and to the right.
Conclusion: These data suggest that exogenous H2S exerts a facilitatory role on isolated CSB through opening KATP channels and further closing the calcium channels in vascular smooth muscle. Endogenous H2S may activate the activity of the CSB in vivo. },
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3759}
}