TY - JOUR AU - Kong Ling-na AU - Zuo Ping-ping AU - Mu Liang AU - Liu Yan-yong AU - Yang Nan PY - 2016 TI - Gene expression profile of amyloid beta protein-injected mouse model for Alzheimer disease JF - Acta Pharmacologica Sinica; Vol 26, No 6 (June 2005): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Aim: To investigate the gene expression profile changes in the cerebral cortex of mice injected icv with amyloid beta-protein (Abeta) fragment 25-35 using cDNA microarray. Methods: Balb/c mice were randomly divided into a control group and Abeta-treated group. The Morris water maze test was performed to detect the peffect of Abeta-injection on the learning and memory of mice. Atlas Mouse 1.2 Expression Arrays containing 1176 genes were used to investigate the gene expression pattern of each group. Results: The gene expression profiles showed that 19 genes including TBX 1, NF - kappa B, AP-1/c-Jun , cadherin, integrin, erb-B2 , and FGFR1 were up-regulated after 2 weeks of icv administration of Abeta; while 12 genes were down-regulated, including NGF, glucose phosphate isomerase 1, AT motif binding factor 1, Na + /K + -ATPase , and Akt . Conclusion: The results provide important leads for pursuing a more complete understanding of the molecular events of Abeta-injection into mice with Alzheimer disease. UR - http://www.chinaphar.com/article/view/3752