@article{APS3743,
author = {Irena Manov and Helen Motanis and Idan Frumin and Theodore C Iancu},
title = {Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects},
journal = {Acta Pharmacologica Sinica},
volume = {27},
number = {3},
year = {2016},
keywords = {},
abstract = {With the increasing incidence of drug-induced liver disease, attempts are being made to better understand the mechanisms behind these frequently life-endangering reactions. Analgesics and anti-inflammatory drugs are a major group exhibiting hepatotoxicity. We review research relating to these reactions, focusing on ultrastructural findings, which may contribute to the comprehension and possible avoidance of drug-induced liver disease. We also present some original observations on clinical material and cultured cells exposed to acetaminophen alone or in combination with the antioxidant N-acetylcysteine or the P-glycoprotein inhibitor verapamil.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3743}
}