@article{APS3725,
author = {Jing Wu and Wei Kou and Ming-tai Gao and Yong-ning Zhou and Ai-qin Wang and Qun-ji Xue and Liang Qiao},
title = {Effects of \{2-[(3-carboxy-1-oxoprogy1)amino]-2-deoxy- D -glucose\} on human hepatocellular carcinoma cell line},
journal = {Acta Pharmacologica Sinica},
volume = {26},
number = {5},
year = {2016},
keywords = {},
abstract = {Aim: To study the effects of \{2-[(3-carboxy-1-oxoprogy1)amino]-2-deoxy-D-glucose (COPADG) on cultured human hepatocellular carcinoma cells (HepG2).
Methods: HepG2 cells were cultured in RPMI-1640 medium. Cell proliferation was determined by MTT assay. Apoptosis was determined by fluorescence microscopy, transmission electron microscopy, agarose gel electrophoresis of DNA fragmentation, and flow cytometry.
Results: At the concentration ranging between 1–30 mumol/L, COPADG potently inhibited the growth and induced apoptosis of HepG2 cells.
Conclusion: COPADG could effectively induce apoptosis in human hepatocellular carcinoma cells. More investigations are warranted for the potential use of this compound as a new agent for the non-surgical management of human hepatocellular carcinoma.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3725}
}