@article{APS3626,
author = {Qin-gui Xia and Alexander Reinecke and Marc Dorenkamp and Mat Jap Daemen and Reichiger Simon and Thomas Unger},
title = {Effects of endothelin ETA receptor blocker LU 135252 on cardiac remodeling and survival in a hypertensive rat model of chronic heart failure},
journal = {Acta Pharmacologica Sinica},
volume = {27},
number = {11},
year = {2016},
keywords = {},
abstract = {Aim: To investigate whether the endothelin ETA receptor blocker provides similar benefit on cardiac remodeling and survival in a hypertensive rat model of chronic heart failure (CHF).
Methods: Male stroke-prone spontaneously hypertensive (SHR-SP) rats were subjected to permanent ligation of the left coronary artery and were treated for 6 weeks with the endothelin ETA receptor blocker LU 135252 (30 mgkg-1d-1) starting 24 h after ligation or untreatment. Sham-operated rats served as normal controls. The mean arterial blood pressure (MAP), heart rate (HR), left ventricular end-diastolic pressure (LVEDP), left ventricular contractility (LV dp/dtmax), left ventricular inner diameter (LVD) and circumference (LVC), septal thickness, left ventricular interstitial collagen content (ICC) and heart weight (HW) were measured at the end of the treatment.
Results: Compared with the untreated group, LU 135252 tended to increase HW (1.43±0.03 vs 1.38±0.04 g; P>0.05), increased LVD (7.65±0.24 mm vs 6.58±0.14 mm; P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3626}
}