TY  - JOUR
AU  - Zhang Xiao-fei
AU  - Yang Rui-fang
AU  - Wang Jin
AU  - Zhao Lei
AU  - Li Ling
AU  - Shen Fu-ming
AU  - Su Ding-feng
PY  - 2016
TI  - Arterial baroreflex function does not influence telomere length in kidney of rats
JF  - Acta Pharmacologica Sinica; Vol 27, No 11 (November 2006): Acta Pharmacologica Sinica
Y2  - 2016
KW  - 
N2  - Aim: To investigate the relationship between arterial baroreflex (ABR) function and telomere length in kidney of rats.  Methods: Stroke-prone spontaneously hypertensive rats (SHR-SP) and sinoaortic denervated rats (SAD) were used as models with depressed arterial baroreflex. In the first experiments, SHR-SP rats were examined at the age of 24 weeks for both sexes and 40 weeks for female rats. In the second experiments, SAD rats were studied 4 and 35 weeks after SAD operation. Blood pressure was continuously recorded for 4 h in a conscious state. After the determination of baroreflex sensitivity (BRS), the terminal restriction fragment (TRF) of rat kidney was analyzed using Southern blot.  Results: The TRF length was found shorter in: a) male SHR-SP compared with age-matched female SHR-SP; b) female SHR-SP 40 weeks of age compared with 24 weeks of age; c) in rats 35 weeks after operation compared with rats 4 weeks post operation in both sham-operated and SAD rats.  Conclusion: In SHR-SP, the TRF length did not correlate with BRS. In addition, SAD did not affect TRF length at either 4 or 35 weeks post-surgery. It may be concluded that baroreflex function does not influence the terminal restriction fragment (TRF) length in rats.
UR  - http://www.chinaphar.com/article/view/3625