@article{APS3579,
author = {Marc PILON and Catarina MORCK},
title = {Development of Caenorhabditis elegans pharynx, with emphasis on its nervous system},
journal = {Acta Pharmacologica Sinica},
volume = {26},
number = {4},
year = {2016},
keywords = {},
abstract = {The Caenorhabditis elegans pharynx is a neuromuscular tube of which the function
is to pump and crush bacteria, and inject them into the intestine. The 80-cell
pharynx develops via the morphogenesis and differentiation of the cells that compose
its semi-spherical primordium, and requires the activity of several evolutionarily
conserved genes, such as pha-4 (the homolog to the Drosophila forkhead
and vertebrate FoxA), ceh-22 (the homolog to the Drosophila tinman and vertebrate
Nkx2.5), and pha-2 (the homolog to the vertebrate Hex). There are 20 neurons
in the pharynx, each with a reproducible unique trajectory. Developmental
genetic analysis of axon guidance in the pharynx indicates that some axon trajectories
are in part established without growth cones, whereas other parts necessitate
growth cone function and guidance. Here we provide an overview of the
developmental genetics of the Caenorhabditis elegans pharynx, with an emphasis
on its nervous system.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3579}
}