TY - JOUR AU - LI Dan-dan AU - CHEN Jun-hua AU - CHEN Qing AU - LI Guo-wei AU - CHEN Jing AU - YUE Jian-min AU - CHEN Min-li AU - WANG Xiao-ping AU - SHEN Jian-hua AU - SHEN Xu AU - JIANG Hua-liang PY - 2016 TI - Swietenia mahagony extract shows agonistic activity to PPARγ and gives ameliorative effects on diabetic db/db mice JF - Acta Pharmacologica Sinica; Vol 26, No 2 (February 2005): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Aim: To search the peroxisome proliferator-activated receptor γ (PPARγ) agonists from Swietenia mahagony extract (SmE) and observe the possible ameliorative effects of Sm E on diabetic db/db mice. Methods: The PPARγ agonistic activity of Sm E was screened by yeast-two hybrid system. The blood glucose levels of diabetic db/db mice were measured using a blood glucose level monitor and the data were statistically analyzed by NDST8.8W software. Results: By using the clinical drug rosiglitazone as a positive control, it was found that the PPARγ agonistic activity of Sm E at a concentration of 50 μg/L was approximately half that of 35.7 μg/L (0.1 μmol/L) of rosiglitazone. At the dose of 1000 mg/kg, Sm E remarkably decreased the blood glucose concentration of db/db mice from (15.26±2.98) to (7.58±2.20) mmol/L, and reduced the blood glucose levels by 55.49% compared with the control group ( P Conclusion: Sm E shows agonistic activity to PPARγ and can ameliorate the blood glucose levels of diabetic db/db mice. Sm E may be thus used as a potential agent for diabetes therapy. UR - http://www.chinaphar.com/article/view/3551