@article{APS3546,
author = {Zhi-jun GE and Yin-ming ZENG and Yong-fei TAN},
title = {Effects of intrathecal 6-hydroxydopamine, α 1 and α 2 adrenergic receptor antagonists on antinociception of propofol in mice},
journal = {Acta Pharmacologica Sinica},
volume = {26},
number = {2},
year = {2016},
keywords = {},
abstract = {Aim: To investigate the relationship between spinal cord norepinephrine, α1 and
α2 adrenergic receptors and antinociception of propofol in mice. Methods:
Kunming mice were used. Antinociceptive tests were investigated with the tailimmersion
test and the acetic acid-induced writhing test. The effects of subcutaneous
(sc), intrathecal (ith) and intracerebroventricular (icv) injection propofol
on pain threshold were observed. The influences of pretreatment with ith 6-
hydroxydopamine, α1R antagonist prazosin, or α2R antagonist yohimbine on the
antinociception of propofol were studied. Results: Significant antinociception
was produced by propofol (25, 50 mg/kg, sc) and propofol (20, 40 μg, ith) in tailimmersion
test and acetic the acid-induced writhing test (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3546}
}