%0 Journal Article %T Using support vector classification for SAR of fentanyl derivatives 1 %A DONG Ning %A LU Wen-cong %A CHEN Nian-yi %A ZHU You-cheng %A CHEN Kai-xian %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Using support vector classification for SAR of fentanyl derivatives 1 %K %X Aim: To discriminate between fentanyl derivatives with high and low activities. Methods: The support vector classification (SVC) method, a novel approach, was employed to investigate structure-activity relationship (SAR) of fentanyl derivatives based on the molecular descriptors, which were quantum parameters including △E [energy difference between highest occupied molecular orbital energy (HOMO) and lowest empty molecular orbital energy (LUMO)], MR (molecular refractivity) and Mr (molecular weight). Results: By using leave-oneout cross-validation test, the accuracies of prediction for activities of fentanyl derivatives in SVC, principal component analysis (PCA), artificial neural network (ANN) and K-nearest neighbor (KNN) models were 93%, 86%, 57%, and 71%, respectively. The results indicated that the performance of the SVC model was better than those of PCA, ANN, and KNN models for this data. Conclusion: SVC can be used to investigate SAR of fentanyl derivatives and could be a promising tool in the field of SAR research. %U http://www.chinaphar.com/article/view/3533 %V 26 %N 1 %P 107-112 %@ 1745-7254