TY - JOUR AU - Shen Jin-kang AU - Zhang Hai-tao PY - 2023 TI - Function and structure of bradykinin receptor 2 for drug discovery JF - Acta Pharmacologica Sinica; Vol 44, No 3 (March 2023): Acta Pharmacologica Sinica Y2 - 2023 KW - N2 - Type 2 bradykinin receptor (B2R) is an essential G protein-coupled receptor (GPCR) that regulates the cardiovascular system as a vasodepressor. Dysfunction of B2R is also closely related to cancers and hereditary angioedema (HAE). Although several B2R agonists and antagonists have been developed, icatibant is the only B2R antagonist clinically used for treating HAE. The recently determined structures of B2R have provided molecular insights into the functions and regulation of B2R, which shed light on structure-based drug design for the treatment of B2R-related diseases. In this review, we summarize the structure and function of B2R in relation to drug discovery and discuss future research directions to elucidate the remaining unknown functions of B2R dimerization. UR - http://www.chinaphar.com/article/view/10778