@article{APS10667,
author = {Shuang Liu and Man Liu and Meng-lin Zhang and Cui-zhe Wang and Yin-liang Zhang and Yu-jie Zhang and Chun-yuan Du and Su-fang Sheng and Wei Wang and Ya-tong Fan and Jia-ni Song and Jin-can Huang and Yue-yao Feng and Wei Qiao and Jin-long Huang and Yu-hui Li and Lu Zhou and Jun Zhang and Yong-sheng Chang},
title = {Transcription factor Klf9 controls bile acid reabsorption and enterohepatic circulation in mice via promoting intestinal Asbt expression},
journal = {Acta Pharmacologica Sinica},
volume = {43},
number = {9},
year = {2022},
keywords = {},
abstract = {Bile acid (BA) homeostasis is regulated by the extensive cross-talk between liver and intestine. Many bile-acid-activated signaling pathways have become attractive therapeutic targets for the treatment of metabolic disorders. In this study we investigated the regulatory mechanisms of BA in the intestine. We showed that the BA levels in the gallbladder and faeces were significantly increased, whereas serum BA levels decreased in systemic Krüppel-like factor 9 (Klf9) deficiency (Klf9−/−) mice. These phenotypes were also observed in the intestine-specific Klf9-deleted (Klf9vil−/−) mice. In contrast, BA levels in the gallbladder and faeces were reduced, whereas BA levels in the serum were increased in intestinal Klf9 transgenic (Klf9Rosa26+/+) mice. By using a combination of biochemical, molecular and functional assays, we revealed that Klf9 promoted the expression of apical sodium-dependent bile acid transporter (Asbt) in the terminal ileum to enhance BA absorption in the intestine. Reabsorbed BA affected liver BA synthetic enzymes by regulating Fgf15 expression. This study has identified a previously neglected transcriptional pathway that regulates BA homeostasis.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/10667}
}