TY - JOUR AU - Griffett Kristine AU - Hayes Matthew E. AU - Boeckman Michael P. AU - Burris Thomas P. PY - 2022 TI - The role of REV-ERB in NASH JF - Acta Pharmacologica Sinica; Vol 43, No 5 (May 2022): Acta Pharmacologica Sinica Y2 - 2022 KW - N2 - REV-ERBs are atypical nuclear receptors as they function as ligand-regulated transcriptional repressors. The natural ligand for the REV-ERBs (REV-ERBĪ± and REV-ERBĪ²) is heme, and heme-binding results in recruitment of transcriptional corepressor proteins such as N-CoR that mediates repression of REV-ERB target genes. These two receptors regulate a large range of physiological processes including several important in the pathophysiology of non-alcoholic steatohepatitis (NASH). These include carbohydrate and lipid metabolism as well as inflammatory pathways. A number of synthetic REV-ERB agonists have been developed as chemical tools and they show efficacy in animal models of NASH. Here, we will review the functions of REV-ERB with regard to their relevance to NASH as well as the potential to target REV-ERB for treatment of this disease. UR - http://www.chinaphar.com/article/view/10551