%0 Journal Article %T The role of REV-ERB in NASH %A Griffett Kristine %A Hayes Matthew E. %A Boeckman Michael P. %A Burris Thomas P. %J Acta Pharmacologica Sinica %D 2022 %B 2022 %9 %! The role of REV-ERB in NASH %K %X REV-ERBs are atypical nuclear receptors as they function as ligand-regulated transcriptional repressors. The natural ligand for the REV-ERBs (REV-ERBα and REV-ERBβ) is heme, and heme-binding results in recruitment of transcriptional corepressor proteins such as N-CoR that mediates repression of REV-ERB target genes. These two receptors regulate a large range of physiological processes including several important in the pathophysiology of non-alcoholic steatohepatitis (NASH). These include carbohydrate and lipid metabolism as well as inflammatory pathways. A number of synthetic REV-ERB agonists have been developed as chemical tools and they show efficacy in animal models of NASH. Here, we will review the functions of REV-ERB with regard to their relevance to NASH as well as the potential to target REV-ERB for treatment of this disease. %U http://www.chinaphar.com/article/view/10551 %V 43 %N 5 %P 1133–1140 %@ 1745-7254