@article{APS10382,
author = {Xin Zhang and Can Hu and Hai-ming Wu and Zhen-guo Ma and Qi-zhu Tang},
title = {Fibronectin type III domain-containing 5 in cardiovascular and metabolic diseases: a promising biomarker and therapeutic target},
journal = {Acta Pharmacologica Sinica},
volume = {42},
number = {9},
year = {2021},
keywords = {},
abstract = {Cardiovascular and metabolic diseases are the leading causes of death and disability worldwide and impose a tremendous socioeconomic burden on individuals as well as the healthcare system. Fibronectin type III domain-containing 5 (FNDC5) is a widely distributed transmembrane glycoprotein that can be proteolytically cleaved and secreted as irisin to regulate glycolipid metabolism and cardiovascular homeostasis. In this review, we present the current knowledge on the predictive and therapeutic role of FNDC5 in a variety of cardiovascular and metabolic diseases, such as hypertension, atherosclerosis, ischemic heart disease, arrhythmia, metabolic cardiomyopathy, cardiac remodeling, heart failure, diabetes mellitus, and obesity.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/10382}
}