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Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

  
@article{APS10191,
	author = {Yuan Huang and Chan Yang and Xin-feng Xu and Wei Xu and Shu-wen Liu},
	title = {Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19},
	journal = {Acta Pharmacologica Sinica},
	volume = {41},
	number = {9},
	year = {2020},
	keywords = {},
	abstract = {Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell membrane fusion process, is composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain that recognizes and binds to the host receptor angiotensin-converting enzyme 2, while the S2 subunit mediates viral cell membrane fusion by forming a six-helical bundle via the two-heptad repeat domain. In this review, we highlight recent research advance in the structure, function and development of antivirus drugs targeting the S protein.},
	url = {http://www.chinaphar.com/article/view/10191}
}