TY - JOUR AU - Yuan Meng AU - Song Zi-han AU - Ying Mei-dan AU - Zhu Hong AU - He Qiao-jun AU - Cao Bo Yang and Ji AU - Cao Ji PY - 2020 TI - N-myristoylation: from cell biology to translational medicine JF - Acta Pharmacologica Sinica; Vol 41, No 8 (August 2020): Acta Pharmacologica Sinica Y2 - 2020 KW - N2 - Various lipids and lipid metabolites are bound to and modify the proteins in eukaryotic cells, which are known as ‘protein lipidation’. There are four major types of the protein lipidation, i.e. myristoylation, palmitoylation, prenylation, and glycosylphosphatidylinositol anchor. N-myristoylation refers to the attachment of 14-carbon fatty acid myristates to the N-terminal glycine of proteins by N-myristoyltransferases (NMT) and affects their physiology such as plasma targeting, subcellular tracking and localization, thereby influencing the function of proteins. With more novel pathogenic N-myristoylated proteins are identified, the N-myristoylation will attract great attentions in various human diseases including infectious diseases, parasitic diseases, and cancers. In this review, we summarize the current understanding of N-myristoylation in physiological processes and discuss the hitherto implication of crosstalk between N-myristoylation and other protein modification. Furthermore, we mention several well- studied NMT inhibitors mainly in infectious diseases and cancers and generalize the relation of NMT and cancer progression by browsing the clinic database. This review also aims to highlight the further investigation into the dynamic crosstalk of N- myristoylation in physiological processes as well as the potential application of protein N-myristoylation in translational medicine. UR - http://www.chinaphar.com/article/view/10176