TY - JOUR AU - Zhong Xiao-fang AU - Sun Xun PY - 2020 TI - Nanomedicines based on nanoscale metal-organic frameworks for cancer immunotherapy JF - Acta Pharmacologica Sinica; Vol 41, No 7 (July 2020): Acta Pharmacologica Sinica Y2 - 2020 KW - N2 - Cancer immunotherapy, with an aim to enhance host immune responses, has been recognized as a promising therapeutic treatment for cancer. A diversity of immunomodulatory agents, including tumor-associated antigens, adjuvants, cytokines and immunomodulators, has been explored for their ability to induce a cascading adaptive immune response. Nanoscale metal-organic frameworks (nMOFs), a class of crystalline-shaped nanomaterials formed by the self-assembly of organic ligands and metal nodes, are attractive for cancer immunotherapy because they feature tunable pore size, high surface area and loading capacity, and intrinsic biodegradability. In this review we summarize recent progress in the development of nMOFs for cancer immunotherapy, including cancer vaccine delivery and combination of in situ vaccination with immunomodulators to reverse immune suppression. Current challenges and future perspectives for rational design of nMOF-based cancer immunotherapy are also discussed. UR - http://www.chinaphar.com/article/view/10169