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Integrating yeast chemical genomics and mammalian cell pathway analysis

	author = {Fu-lai Zhou and Sheena C Li and Yue Zhu and Wan-jing Guo and Li-jun Shao and Justin Nelson and Scott Simpkins and De-hua Yang and Qing Liu and Yoko Yashiroda and Jin-biao Xu and Yao-yue Fan and Jian-min Yue and Minoru Yoshida and Tian Xia and Chad L Myers and Charles Boone and Ming-wei Wang},
	title = {Integrating yeast chemical genomics and mammalian cell pathway analysis},
	journal = {Acta Pharmacologica Sinica},
	volume = {40},
	number = {9},
	year = {2019},
	keywords = {},
	abstract = {Chemical genomics has been applied extensively to evaluate small molecules that modulate biological processes in Saccharomyces cerevisiae. Here, we use yeast as a surrogate system for studying compounds that are active against metazoan targets. Large-scale chemical-genetic profiling of thousands of synthetic and natural compounds from the Chinese National Compound Library identified those with high-confidence bioprocess target predictions. To discover compounds that have the potential to function like therapeutic agents with known targets, we also analyzed a reference library of approved drugs. Previously uncharacterized compounds with chemical-genetic profiles resembling existing drugs that modulate autophagy and Wnt/β-catenin signal transduction were further examined in mammalian cells, and new modulators with specific modes of action were validated. This analysis exploits yeast as a general platform for predicting compound bioactivity in mammalian cells.},
	url = {}