The role of the dynorphin/κ opioid receptor system in anxiety

Ai HANG, Yu-jun WANG, Ling HE, Jing-gen LIU
DOI: 10.1038/aps.2015.32


Anxiety disorders are the most common and prevalent forms of psychiatric disease, although the biological basis of anxiety is not well understood. The dynorphin/κ opioid receptor system is widely distributed in the central nervous system and has been shown to play a critical role in modulating mood and emotional behaviors. In the present review, we summarize current literature relating to the role played by the dynorphin/κ opioid receptor system in anxiety and κ opioid receptor antagonists as potential therapeutic agents for the treatment of anxiety disorders.
Keywords: dynorphin; κ opioid receptor; stress; anxiety

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