Original Article

Influence of nimodipine on elimination of soman in rabbit blood and distribution of [3H]soman in mice.

Authors: Jin-Tong LI, Jin-Xiu RUAN, Shu-Lan YUAN, Zhen-Qing ZHANG, Zheng-Yan SONG, Xiao-Ying WANG

Abstract

AIM: To investigate the effect of nimodipine on the elimination of soman in
rabbit blood and distribution of [3H]soman in mice.
METHODS: Chirasil capillary gas chromatographic analysis method with large volume
injections was used to determine the concentration of C(+/-)P(-)soman in rabbit
blood. [3H]soman trace method was used to study the effect of nimodipine on soman
distribution in mice.
RESULTS: Nimodipine (10 mg/kg, ip, 1 h pre-treated) could significantly reduce
the concentration of C(+/-)P(-)soman in rabbit blood from (54+/-13) to (19+/-12)
microg/L blood at 15 s after soman injection (43.2 microg/kg, iv). Nimodipine
could increase clearance rate [CL(S)] from (20.8+/-1.5) to (31+/-11) mL/kg/s and
reduce AUC of C(+/-)P(-)soman from (2.08+/-0.15) to (1.6+/-0.4) mg/s. Nimodipine
(10 mg/kg, ip, 1 h pre-treated) treatment could significantly reduce the
distribution amount of bound [3H]soman in plasma, brain, lung, and liver,
moreover increased the distribution amount of bound [3H]soman in small intestine
during 0-120 min after mice received [3H]soman (0.544 GBq*119 microg/kg, sc)
compared to soman control group.
CONCLUSION: Nimodipine might alter the distribution of soman and reduce the
initial concentration of soman in rabbit blood, then accelerated the metabolic
detoxication of soman.
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