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Review

Lowering serum lipids via PCSK9-targeting drugs: current advances and future perspectives [P 301-311]
Ni-ya HE, Qing LI, Chun-yan WU, Zhong REN, Ya GAO, Li-hong PAN, Mei-mei WANG, Hong-yan WEN, Zhi-sheng JIANG, Zhi-han TANG, Lu-shan LIU
[ Abstract ][ Full text ]

Brain cannabinoid receptor 2: expression, function and modulation [P 312-316]
De-jie CHEN, Ming GAO, Fen-fei GAO, Quan-xi SU, Jie WU
[ Abstract ][ Full text ]


Original Article

Cardiovascular Pharmacology 

2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside protects murine hearts against ischemia/reperfusion injury by activating Notch1/Hes1 signaling and attenuating endoplasmic reticulum stress [P 317-330]
Meng ZHANG, Li-ming YU , Hang ZHAO, Xuan-xuan ZHOU, Qian YANG, Fan SONG, Li YAN, Meng-en ZHAI, Bu-ying LI, Bin ZHANG, Zhen-xiao JIN, Wei-xun DUAN, Si-wang WANG
[ Abstract ][ Full text ]

Luteolin-7-diglucuronide attenuates isoproterenol-induced myocardial injury and fibrosis in mice [P 331-341]
Bing-bing NING, Yong ZHANG, Dan-dan WU, Jin-gang CUI, Li LIU, Pei-wei WANG, Wen-jian WANG, Wei-liang ZHU, Yu CHEN, Teng ZHANG
[ Abstract ][ Full text ]


Pulmonary Pharmacology

LYRM03, an ubenimex derivative, attenuates LPS-induced acute lung injury in mice by suppressing the TLR4 signaling pathway [P 342-350]
Hui-qiong HE, Ya-xian WU, Yun-juan NIE, Jun WANG, Mei GE, Feng QIAN
[ Abstract ][ Full text ]


Endocrine Pharmacology

In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine [P 351-361]
Na YANG, Run-bin SUN, Xing-long CHEN, Le ZHEN, Chun GE, Yu-qing ZHAO, Jun HE, Jian-liang GENG, Jia-hua GUO, Xiao-yi YU, Fei FEI, Si-qi FENG, Xuan-xuan ZHU, Hong-bo WANG, Feng-hua FU, Ji-ye AA, Guang-ji WANG 
[ Abstract ][ Full text ]

A mini-network balance model for evaluating the progression of cardiovascular complications in Goto-Kakizaki rats [P 362-370]
Hao JIANG, Yu-hao WANG, Chun-xiang WEI, Xue ZHANG, Hao-chen LIU, Xiao-quan LIU  
[ Abstract ][ Full text ]


Chemotherapy and Antimicrobial

The lncRNA XIST exhibits oncogenic properties via regulation of miR-449a and Bcl-2 in human non-small cell lung cancer [P 371-381]
Ya-long ZHANG, Xue-bing LI, Yan-xu HOU, Nian-zhen FANG, Jia-cong YOU, Qing-hua ZHOU  
[ Abstract ][ Full text ]

The PI3K/mTOR dual inhibitor BEZ235 suppresses proliferation and migration and reverses multidrug resistance in acute myeloid leukemia [P 382-391]
Lan DENG, Ling JIANG, Xiang-hua LIN, Kuo-fu TSENG, Yuan LIU, Xing ZHANG, Rui-hong DONG, Zhi-gang LU, Xiu-ju WANG  
[ Abstract ][ Full text ]

Rheum emodin inhibits enterovirus 71 viral replication and affects the host cell cycle environment [P 392-401]
Ting ZHONG, Li-ying ZHANG, Zeng-yan WANG, Yue WANG, Feng-mei SONG, Ya-hong ZHANG, Jing-hua YU 
[ Abstract ][ Full text ]

BX-795 inhibits HSV-1 and HSV-2 replication by blocking the JNK/p38 pathways without interfering with PDK1 activity in host cells [P 402-414]
Ai-rong SU, Min QIU, Yan-lei LI, Wen-tao XU, Si-wei SONG, Xiao-hui WANG, Hong-yong SONG, Nan ZHENG, Zhi-wei WU  
[ Abstract ][ Full text ]


Clinical Pharmacology

IL-3 and CTLA4 gene polymorphisms may influence the tacrolimus dose requirement in Chinese kidney transplant recipients [P 415-423]
Mou-ze LIU, Hai-yan HE, Yue-li ZHANG, Yong-fang HU, Fa-zhong HE, Jian-quan LUO, Zhi-ying LUO, Xiao-ping CHEN, Zhao-qian LIU, Hong-hao ZHOU, Ming-jie SHAO, Ying-zi MING, Hua-wen XIN, Wei ZHANG  
[ Abstract ][ Full text ]


Pharmaceutics

Soluplus micelles for improving the oral bioavailability of scopoletin and their hypouricemic effect in vivo [P 424-433]
Ying-chun ZENG, Sha LI, Chang LIU, Tao GONG, Xun SUN, Yao FU, Zhi-rong ZHANG  
[ Abstract ][ Full text ]


Absorption, Distribution, Metabolism, and Excretion

Development of a novel individualized warfarin dose algorithm based on a population pharmacokinetic model with improved prediction accuracy for Chinese patients after heart valve replacement [P 434-442]
Yu-bin ZHU, Xian-hua HONG, Meng WEI, Jing HU, Xin CHEN, Shu-kui WANG, Jun-rong ZHU, Feng YU, Jian-guo SUN  
[ Abstract ][ Full text ]


Erratum

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Acknowledgements

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