Editorial

Channelopathies and drug discovery in the era of postgenome [P 673-674]
Dayue Darrel DUAN, Tong-hui MA
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Review

Chloride channelopathies

The ClC-3 chloride channels in cardiovascular disease [P 675-684]
Dayue Darrel DUAN
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Physiological roles and diseases of tmem16/anoctamin proteins: are they all chloride channels? [P 685-692]
Charity DURAN, H Criss HARTZELL
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Targeting F508del-CFTR to develop rational new therapies for cystic fibrosis [P 693-701]
Zhi-wei CAI, Jia LIU, Hong-yu LI, David N SHEPPARD
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Aquaporinopathies

Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica [P 702-710]
Alan S VERKMAN, Julien RATELADE, Andrea ROSSI, Hua ZHANG, Lukmanee TRADTRANTIP
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Expression and function of aquaporins in peripheral nervous system [P 711-715]
Tong-hui MA, Hong-wen GAO, Xue-dong FANG, Hong YANG
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Maternal-fetal fluid balance and aquaporins: from molecule to physiology [P 716-720]
Xiao-yan SHA, Zheng-fang XIONG, Hui-shu LIU, Xiao-dan DI, Tong-hui MA
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Aquaporins in sperm osmoadaptation: an emerging role for volume regulation [P 721-724]
Qi CHEN, En-kui DUAN
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Calcium and channelopathies

TRPM7 in cerebral ischemia and potential target for drug development in stroke [P 725-733]
Christine You-jin BAE, Hong-shuo SUN
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Calcium-permeable ion channels involved in glutamate receptor-independent ischemic brain injury [P 734-740]
Ming-hua LI, Koichi INOUE, Hong-fang SI, Zhi-gang XIONG
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Calcium binding protein-mediated regulation of voltage-gated calcium channels linked to human diseases [P 741-748]
Nasrin NEJATBAKHSH, Zhong-ping FENG
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Targeting ryanodine receptors for anti-arrhythmic therapy [P 749-757]
Mark D McCAULEY, Xander H T WEHRENS
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Potassium channelopathies

A role of stretch-activated potassium currents in the regulation of uterine smooth muscle contraction [P 758-764]
Iain L O BUXTON, Nathanael HEYMAN, Yi-ying WU, Scott BARNETT, Craig ULRICH
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Current understanding of K_ATP channels in neonatal diseases: focus on insulin secretion disorders [P 765-780]
Yi QUAN, Andrew BARSZCZYK, Zhong-ping FENG, Hong-shuo SUN
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Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules [P 781-788]
Ping-zheng ZHOU, Joseph BABCOCK, Lian-qing LIU, Min LI, Zhao-bing GAO
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Sodium channelopathy

Role of the epithelial sodium channel in salt-sensitive hypertension [P 789-797]
Yan SUN, Jia-ning ZHANG, Dan ZHAO, Qiu-shi WANG, Yu-chun GU, He-ping MA, Zhi-ren ZHANG
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Laminopathy and drug discovery

Beyond membrane channelopathies: alternative mechanisms underlying complex human disease [P 798-804]
Konstantinos Dean BOUDOULAS, Peter J MOHLER
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Polycystic kidney discease and drug discovery

Drug discovery for polycystic kidney disease [P 805-816]
Ying SUN, Hong ZHOU, Bao-xue YANG
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Arrhythmia and anesthetics

Propofol and arrhythmias: two sides of the coin [P 817-823]
Qiang LIU, Ai-ling KONG, Rong CHEN, Cheng QIAN, Shao-wen LIU, Bao-gui SUN, Le-xin WANG, Long-sheng SONG, Jiang HONG
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Original Article

Characterization of a critical role for CFTR chloride channels in cardioprotection against ischemia/reperfusion injury [P 824-833]
Sunny Yang XIANG, Linda L YE, Li-lu Marie DUAN, Li-hui LIU, Zhi-dong GE, John A AUCHAMPACH, Garrett J GROSS, Dayue Darrel DUAN
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CFTR chloride channel as a molecular target of anthraquinone compounds in herbal laxatives [P 834-839]
Hong YANG, Li-na XU, Cheng-yan HE, Xin LIU, Rou-yu FANG, Tong-hui MA  
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Pregnant phenotype in aquaporin 8-deficient mice [P 840-844]
Xiao-yan SHA, Zheng-fang XIONG, Hui-shu LIU, Zheng ZHENG, Tong-hui MA  
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Enhanced salt sensitivity following shRNA silencing of neuronal TRPV1 in rat spinal cord [P 845-852]
Shuang-quan YU, Donna H WANG  
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Nanomechanical analysis of insulinoma cells after glucose and capsaicin stimulation using atomic force microscopy [P 853-860]
Rui-guo YANG, Ning XI, King Wai-chiu LAI, Bei-hua ZHONG, Carmen Kar-man FUNG, Chen-geng QU, Donna H WANG  
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