Acta Pharmacologica Sinica (2009) 30: 784-787; doi: 10.1038/aps.2009.49

Acta Pharmacologica Sinica (2009) 30: 784-787; doi: 10.1038/aps.2009.49; published online 11 May 2009

Review

Impact of cigarette smoking in type 2 diabetes development

Xi-tao XIE¹, Qiang LIU², Jie WU², Makoto WAKUI^3,*

¹Center for Metabolic Biology, Arizona State University, Tempe, AZ 85287?704, USA; ²Division of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013?496, USA; ³Division of Clinical Research, Hirosaki National Hospital, Hirosaki 036?545, Japan

Many patients with type 2 diabetes mellitus (DM2) are at risk for micro and macro vascular complications, which could be observed in heavy smokers. Cigarette smoking increases the risk for type 2 diabetes incidence. Nicotine, acknowledged as the major pharmacologically active chemical in tobacco, is responsible for the association between cigarette smoking and development of diabetes. This minireview summarized recent studies on nicotine effects on insulin action and insulin secretion, indicating the impact of nicotine on type 2 diabetes development.

Keywords: smoking; diabetes; nicotinic receptor

We would like to thank S DUDEK and S B SIMONS for advice in preparing the manuscript. Research was supported by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences; the National Natural Science Foundation of China (No 30470900), Natural Science Foundation of Guangdong Province (No 04020253) and SRF for ROCS, SEM.

* Correspondence to Dr Makoto WAKU.
E-mail rinken@hirosaki-lan.hosp.go.jp
Received 2009-03-01 Accepted 2009-03-22

[ Full text ]