Acta Pharmacologica Sinica (2009) 30: 501-512; doi: 10.1038/aps.2009.50

Isothiocyanates are naturally occurring small molecules that are formed from glucosinolate precursors of cruciferous vegetables.  Many isothiocyanates, both natural and synthetic, display anticarcinogenic activity because they reduce activation of carcinogens and increase their detoxification.  Recent studies show that they exhibit anti-tumor activity by affecting multiple pathways including apoptosis, MAPK signaling, oxidative stress, and cell cycle progression.  This review summarizes the current knowledge on isothiocyanates and focuses on their role as potential anti-cancer agents. 

Keywords: isothiocyanate; chemoprevention; anticarcinogenic; antitumor; apoptosis; cell cycle