Original Articles

Neuropharmacology

Polygalasaponin XXXII from Polygala tenuifolia root improves hippocampal-dependent learning and memory   [Page 1211-1219]
Xue W, Hu JF, Yuan YH, Sun JD, Li BY, Zhang DM, Li CJ, Chen NH  
[ Abstract ][ Full text ]

Functional study of the effect of phosphatase inhibitors on KCNQ4 channels expressed in Xenopus oocytes [Page 1220-1226]
Su TR, Chen CH, Huang SJ, Lee CY, Su MC, Chen GH, Li SY, Yang JJ, Lin MJ
[ Abstract ][ Full text ]

Epinephrine, phenylephrine, and methoxamine induce infiltrative anesthesia via α1-adrenoceptors in rats [Page 1227-1236]
Shieh JP, Chu CC , Wang JJ, Lin MT
[ Abstract ][ Full text ]

Cardiovascular Pharmacology  

Polymorphisms of angiotensin-converting enzyme (ACE) and ACE2 are not associated with orthostatic blood pressure dysregulation in hypertensive patients [Page 1237-1244]
Fan XH, Wang YB, Wang H, Sun K, Zhang WL, Song XD, Cheng JZ, Wu HY, Zhou XL, Hui RT  
[ Abstract ][ Full text ]

Inhibitory effects of lithospermic acid on proliferation and migration of rat vascular smooth muscle cells [Page 1245-1252]
Chen L, Wang WY, Wang YP    
[ Abstract ][ Full text ]

Recombinant adeno-associated virus-mediated human kallikrein gene therapy protects against hypertensive target organ injuries through inhibiting cell apoptosis [Page 1253-1261]
Chen YH, Yang CM, Chang SP, Hu ML  
[ Abstract ][ Full text ]

Molecular Pharmacology  

Molecular mechanisms underlying the cholesterol-lowering effect of Ginkgo biloba extract in hepatocytes: a comparative study with lovastatin [Page 1262-1275]
Xie ZQ, Liang G, Zhang L, Wang Q, Qu Y, Gao Y, Lin LB, Ye S, Zhang J, Wang H, Zhao GP, Zhang QH  
[ Abstract ][ Full text ]

Gastrointestinal and Renal Pharmacology

Locality-dependent descending reflex motor activity in the anal canal–cholinergic and nitrergic contributions in the rat model [Page 1276-1282]
Radomirov R, Ivancheva C, Itzev D, Petkova-Kirova P    
[ Abstract ][ Full text ]

N-acetylcysteine infusion reduces the resistance index of renal artery in the early stage of systemic sclerosis [Page 1283-1288]
Rosato E, Cianci R, Barbano B, Menghi G, Gigante A, Rossi C, Zardi EM, Amoroso A, Pisarri S, Salsano F    
[ Abstract ][ Full text ]

Endocrinology

Sodium butyrate and dexamethasone promote exocrine pancreatic gene expression in mouse embryonic stem cells [Page 1289-1296]
Ren M, Yan L, Shang CZ, Cao J , Li FP, Li JY, Cheng H, Min J 
[ Abstract ][ Full text ]

Anti-tumor Pharmacology

n-Butylidenephthalide induced apoptosis in the A549 human lung adenocarcinoma cell line by coupled down-regulation of AP-2α and telomerase activity [Page 1297-1306]
Wei CW, Lin CC, Yu YL, Lin CY, Lin PC, Wu MT, Chen CJ, Chang WL, Lin SZ, Chen YLS, Harn HJ
[ Abstract ][ Full text ]

The anti-tumor properties of two tumstatin peptide fragments in human gastric carcinoma [Page 1307-1315]
Li YJ, Sun LC, He Y, Liu XH, Liu M, Wang QM, Jin XM
[ Abstract ][ Full text ]

Rosiglitazone sensitizes hepatocellular carcinoma cell lines to 5-fluorouracil antitumor activity through activation of the PPARγ signaling pathway [Page 1316-1322]
Cao LQ , Wang XL, Wang Q, Xue P, Jiao XY, Peng HP, Lu HW, Zheng Q, Chen XL, Huang XH, Fu XH, Chen JS
[ Abstract ][ Full text ]

Pharmacokinetics   

Evaluation of CYP 3A activity in humans using three different parameters based on endogenous cortisol metabolism [Page 1323-1329]
Luo X, Li XM, Hu ZY, Cheng ZN  
[ Abstract ][ Full text ]

An improved LC-MS/MS method for quantitative determination of ilaprazole and its metabolites in human plasma and its application to a pharmacokinetic study [Page 1330-1336]
Zhou G, Tan ZR, Zhang W, Ou-Yang DS, Chen Y, Guo D, Liu YZ, Fan L, Deng HW  
[ Abstract ][ Full text ]

Pharmaceutics      

Preparation of albumin nanospheres loaded with gemcitabine and their cytotoxicity against BXPC-3 cells in vitro [Page 1337-1343]
Li JM, Chen W, Wang H, Jin C, Yu XJ, Lu WY, Cui L, Fu DL, Ni QX, Hou HM  
[ Abstract ][ Full text ]

Drug Discovery    

Derivatives of (phenylsulfonamido-methyl)nicotine and (phenylsulfonamido-methyl)thiazole as novel 11β-hydroxysteroid dehydrogenase type 1 inhibitors: synthesis and biological activities in vitro [Page 1344-1350]
Zhang X, Zhou Y, Shen Y, Du LL, Chen JH, Leng Y, Shen JH  
[ Abstract ][ Full text ]

7-Chloroarctinone-b as a new selective PPARγ antagonist potently blocks adipocyte differentiation [Page 1351-1358]
Li YT, Li L, Chen J, Hu TC, Huang J, Guo YW, Jiang HL, Shen X
[ Abstract ][ Full text ]

LGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation [Page 1359-1368]
Zhou YB, Feng X, Wang LN, Du JQ, Zhou YY, Yu HP, Zang Y, Li JY, Li J  
[ Abstract ][ Full text ]

Acknowledgements to Reviewers

Top