Original Articles

Cardiovascular Pharmacology  

α_1D-Adrenergic receptor insensitivity is associated with alterations in its expression and distribution in cultured vascular myocytes [Page 1585-1593]
Fan LL, Ren S, Zhou H, Wang Y, Xu PX, He JQ, Luo DL
[ Abstract ][ Full text ]

Low dose of moxonidine within the rostral ventrolateral medulla improves the baroreflex sensitivity control of sympathetic activity in hypertensive rat [Page 1594-1600]
Wang JL, Wang L, Wu ZT, Yuan WJ, Su DF, Ni X, Yan JJ, Wang WJ    
[ Abstract ][ Full text ]

Renal and Endocrine Pharmacology  

Adenosine 5'-triphosphate stimulates the increase of TGF-β 1 in rat mesangial cells under high-glucose conditions via reactive oxygen species and ERK1/2 [Page 1601-1606]
Qu LP, Xue H, Yuan P, Zhou L, Yao T, Huang Y, Lu LM
[ Abstract ][ Full text ]

Astragalus polysaccharides alleviates glucose toxicity and restores glucose homeostasis in diabetic states via activation of AMPK [Page 1607-1615]
Zou F, Mao XQ, Wang N, Liu J, Ou-Yang JP
[ Abstract ][ Full text ]

Insulin induced translocation of Na⁺/K⁺-ATPase is decreased in the heart of streptozotocin diabetic rats [Page 1616-1624]
Rosta K, Tulassay E, Enzsoly A, Ronai K, Szantho A, Pandics T, Fekete A, Mandl P, Ver A
[ Abstract ][ Full text ]

Ophthalmic Pharmacology  

Downregulation of lentivirus-mediated ILK RNAi on tractional force generation in human retinal Müller cells [Page 1625-1633]
Zheng YP, Liu H, Zeng H, Xiong L, Feng ZH, Sun NX
[ Abstract ][ Full text ]

Molecular and Cellular Pharmacology  

Association between VDR and ESR1 gene polymorphisms with bone and obesity phenotypes in Chinese male nuclear families [Page 1634-1642]
Gu JM, Xiao WJ, He JW, Zhang H, Hu WW, Hu YQ, Li M, Liu YJ, Fu WZ, Yu JB, Gao G, Yue H, Ke YH, Zhang ZL
[ Abstract ][ Full text ]

A novel acute anemia model for pharmacological research in mice by compelled acute exercise [Page 1643-1647]
Liu QS, Wang JH, Cui J, Yang ZH, Du GH
[ Abstract ][ Full text ]

Antitumor Pharmacology  

The combination of baicalin and baicalein enhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells [Page 1648-1658]
Zhou QM, Wang S, Zhang H, Lu YY, Wang XF, Motoo Y, Su SB
[ Abstract ][ Full text ]

Berbamine, a novel nuclear factor κB inhibitor, inhibits growth and induces apoptosis in human myeloma cells  [Page 1659-1665]
Liang Y, Xu RZ, Zhang L, Zhao XY
[ Abstract ][ Full text ]

Toxicology  

In vivo assessment of mitochondrial toxicity of metacavir in Rhesus monkeys after three months of intravenous administration [Page 1666-1673]
Zeng W, Cheng AC, Chen ZL, Luo QH, Sun YB, Li Z, Bi FJ 
[ Abstract ][ Full text ]

Metabonomics  

Application of GC/MS-based metabonomic profiling in studying the lipid-regulating effects of Ginkgo biloba extract on diet-induced hyperlipidemia in rats [Page 1674-1687]
Zhang Q, Wang GJ, A JY, Wu D, Zhu LL, Ma B, Du Y  
[ Abstract ][ Full text ]

Pharmaceutics  

Preparation, characterization, in vivo and in vitro studies of arsenic trioxide Mg-Fe ferrite magnetic nanoparticles [Page 1688-1693]
Yang GF, Li XH, Zhao Z, Wang WB  
[ Abstract ][ Full text ]

Drug Discovery  

Pharmacophore-based virtual screening versus docking-based virtual screening: a benchmark comparison against eight targets [Page 1694-1708]
Chen Z, Li HL, Zhang QJ, Bao XG, Yu KQ, Luo XM, Zhu WL, Jiang HL  
[ Abstract ][ Full text ]

2-Amino-nonyl-6-methoxyl-tetralin muriate inhibits sterol C-14 reductase in the ergosterol biosynthetic pathway [Page 1709-1716]
Liang RM, Cao YB , Fan KH, Xu Y, Gao PH, Zhou YJ, Dai BD, Tan YH, Wang SH, Tang H, Liu HT, Jiang YY
[ Abstract ][ Full text ]