Acta Pharmacologica Sinica 2008 March; 29 (3): 371-375; doi: 10.1111/j.1745-7254.2008.00750.x

Acta Pharmacologica Sinica 2008 March; 29 (3): 371-375; doi: 10.1111/j.1745-7254.2008.00750.x

Original Article

Expression of PLK1 and survivin in non-Hodgkin's lymphoma treated with CHOP

Lin LIU, Min ZHANG, Ping ZOU¹

Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

Aim: The present study was designed to investigate the expression of Polo-like kinase 1 (PLK1) and survivin in non-Hodgkin's lymphoma (NHL).

Methods: The expression of PLK1 and survivin were detected with immunohistochemical techniques.

Results: The expression rate of PLK1 and survivin were 63.6% (56/88) and 79.5% (70/88) in NHL, respectively. PLK1 expression correlated with systemic symptoms, lactate dehydrogenase levels, and international prognostic index scores in B-NHL and T-NHL, while survivin did not.

Conclusion: PLK1 and survivin are both overexpressed in NHL. There is a significant relationship between the overexpression of PLK1 and clinical features.

Keywords: Polo-like kinase 1; survivin; non-Hodgkin's lymphoma

¹Correspondence to prof Ping ZOU.
Phn/Fax 86-27-8572-6387.
E-mail xys387@126.com
Received 2007-07-19 Accepted 2007-10-15

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