Cover: G-protein-coupled receptors (GPCR) are considered the most valuable drug targets in pharmaceutical industry. A universal high-throughputcalcium assay for GPCR modulator screening was developed. Factors that affect assay signal window, including receptor and Gα15/16 expression levels, were studied (page 507-516).

  Vol 29 Issue 4 (2008)  

ORIGINAL ARTICLES

Neuropharmacology

Electrophysiological characterization of a novel Kv channel blocker N,N'-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis(4-methyl)-benzenesulfonamide found in virtual screening [Page 405-412]
Gao ZB, Chen XQ, Jiang HL, Liu H, Hu GY
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Cardiovascular Pharmacology

Differential response of human fetal smooth muscle cells from arterial duct to retinoid acid [Page 413-420]
Wu LH, Xu SJ, Teng JY, Wu W, Ye DY, Wu XZ
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Possible arrhythmiogenic mechanism produced by ibuprofen [Page 421-429]
Yang ZF, Wang HW, Zheng YQ, Zhang Y, Liu YM, Li CZ
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Cellular mechanisms of reduced sarcoplasmic reticulum Ca²⁺ content in L-thyroxin-induced rat ventricular hypertrophy [Page 430-436]
Song LJ, Wang GL, Liu J, Qiu QY, Ou JH, Guan YY
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Molecular Pharmacology

Development of efficient RNA interference system using EGF-displaying phagemid particles [Page 437-442]
Jiang H, Cai XM, Shi BZ, Zhang J, Li ZH, Gu JR
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Endocrine Pharmacology

Chronic palmitate exposure inhibits AMPKα and decreases glucose-stimulated insulin secretion from β-cells: modulation by fenofibrate [Page 443-450]
Sun Y, Ren M, Gao GQ, Gong B, Xin W, Guo H, Zhang XJ, Gao L, Zhao JJ
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Renal Pharmacology

Effect of TGF-β1 antisense oligodeoxynucleotide on renal function in chronic renal failure rats [Page 451-457]
Hiong LC, Voon KL, Abdullah NA, Sattar MA, Rahman NA, Khan AH, Johns EJ
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Levistolide A overcomes P-glycoprotein-mediated drug resistance in human breast carcinoma cells [Page 458-464]
Chen F, Wang T, Wang J, Wang ZQ, Qian M
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Involvement of transcription factor activator protein-2α in doxazosin-induced HeLa cell apoptosis [Page 465-472]
Gan L, Zhu DX, Yang LP, Liu RS, Yan F, Zhang J
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Identification of a natural mutant of HBV X protein truncated 27 amino acids at the COOH terminal and its effect on liver cell proliferation [Page 473-480]
Zhang H, Shan CL, Li N, Zhang X, Zhang XZ, Xu FQ, Zhang S, Qiu LY, Ye LH, Zhang XD
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Antiproliferative effect of rapamycin on human T-cell leukemia cell line Jurkat by cell cycle arrest and telomerase inhibition [Page 481-488]
Zhao YM, Zhou Q, Xu Y, Lai XY, Huang H
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LY294002 induces p53-dependent apoptosis of SGC7901 gastric cancer cells [Page 489-498]
Xing CG, Zhu BS, Liu HH, Lin F, Yao HH, Liang ZQ, Qin ZH
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Anti-inflammation

Purified polysaccharide from Ginkgo biloba leaves inhibits P-selectin-mediated leucocyte adhesion and inflammation [Page 499-506]
Fei R, Fei Y, Zheng S, Gao YG, Sun HX, Zeng XL
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Drug screening

Development of a universal high-throughput calcium assay for G-protein-coupled receptors with promiscuous G-protein Gα15/16 [Page 507-516]
Zhu T, Fang LY, Xie X
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Identification of non-peptidic neuromedin U receptor modulators by a robust homogeneous screening assay [Page 517-527]
Meng T, Su HR, Binkert C, Fischli W, Zhou L, Shen JK, Wang MW
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ANNOUNCEMENT    528