Cover: The figure demonstrates the close-up views of binding modes of quercetin with BChE. It indicates that the phenolic hydroxyls indeed tend to form intermolecular hydrogen bonds with surrounding residues and the flexible structures favor the binding between agents and proteins (page 143-151).

  Vol 29 Issue 2 (2008)  

REVIEWS

Multipotent natural agents to combat Alzheimer's disease. Functional spectrum and structural features [Page 143-151]
Ji HF, Zhang HY
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ORIGINAL ARTICLES

Neuropharmacology

Novel squamosamide derivative (compound FLZ) attenuates Aβ_25-35-induced toxicity in SH-SY5Y cells [Page 152-160]
Fang F, Liu GT
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Modulation of synaptic GABA_A receptor function by zolpidem in substantia nigra pars reticulata [Page 161-168]
Zhang LL, Chen L, Xue Y, Yung WH
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Salvianolic acid B promotes survival of transplanted mesenchymal stem cells in spinal cord-injured rats [Page 169-176]
Bi XB, Deng YB, Gan DH, Wang YZ
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Stereoselectivity of satropane, a novel tropane analog, on iris muscarinic receptor activation and intraocular hypotension [Page 177-184]
Zhu L, Yang LM, Cui YY, Zheng PL, Niu YY, Wang H, Lu Y, Ren QS, Wei PJ, Chen HZ
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Cardiovascular Pharmacology

Two isoforms of cyclooxygenase contribute to augmented endothelium-dependent contractions in femoral arteries of 1-year-old rats [Page 185-192]
Shi Y, Man RYK, Vanhoutte PM
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α_1B-Adrenoceptors mediate adrenergically-induced renal vasoconstrictions in rats with renal impairment [Page 193-203]
Khan MAH, Sattar MA, Abdullah NA, Johns EJ
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Molecular Pharmacology

Fibrinogen interaction of CHO cells expressing chimeric αIIb/αvβ3 integrin [Page 204-210]
Chen JJ, Su XY, Xi XD, Lin LP, Ding J, Lu H
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Double-mismatched siRNAs enhance selective gene silencing of a mutant ALS-causing allele [Page 211-216]
Geng CM, Ding HL
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Phenotypic and molecular characterization of 5 novel CTX-M enzymes carried by Klebsiella pneumoniae and Escherichia coli [Page 217-225]
Cheng J, Ye Y, Wang YY, Li H, Li X, Li JB
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Endocrine Pharmacology

Mitosis orientation in prostate epithelial cells changed by endocrine effect [Page 226-230]
Liu XY, Li DM, Zhang XF, Wu JH, Sun ZY
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Changes of multiple biotransformation phase I and phase II enzyme activities in human fetal adrenals during fetal development [Page 231-238]
Wang H, Ping J, Peng RX, Yue J, Xia XY, Li QX, Kong R, Hong JY
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Antitumor Pharmacology

Toll-like receptor 7 and 9 expression in peripheral blood mononuclear cells from patients with chronic hepatitis B and related hepatocellular carcinoma [Page 239-244]
Xu N, Yao HP, Sun Z, Chen Z
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Immunopharmacology

Tetrandrine suppresses lipopolysaccharide-induced microglial activation by inhibiting NF-κB pathway [Page 245-251]
Xue Y, Wang Y, Feng DC, Xiao BG, Xu LY
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Clinical Pharmacology

Effects of ABCA1 variants on rosiglitazone monotherapy in newly diagnosed type 2 diabetes patients [Page 252-258]
Wang J, Bao YQ, Hu C, Zhang R, Wang CR, Lu JX, Jia WP, Xiang KS
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Toxicology

Cytotoxic effect of CdSe quantum dots on mouse embryonic development [Page 259-266]
Chan WH, Shiao NH
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Drug Screening

Derivatives of aryl-4-guanidinomethylbenzoate and N-aryl-4-guanidinomethylbenzamide as new antibacterial agents: synthesis and bioactivity [Page 267-277]
Yu WY, Yang LX, Xie JS, Zhou L, Jiang XY, Zhu DX, Muramatsu M, Wang MW
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Discovery of a novel competitive inhibitor of PTP1B by high-throughput screening [Page 278-284]
Shi L, Yu HP, Zhou YY, Du JQ, Shen Q, Li JY, Li J
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ANNOUNCEMENTS 230