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Original Articles

Neuropharmacology  

Neuroprotective effect of sodium ferulate and signal transduction mechanisms in the aged rat hippocampus [Page 1399-1408]
Jin Y, Yan EZ, Li XM, Fan Y, Zhao YJ, Liu Z, Liu WZ  
[ Abstract ][ Full text]

Modulation of major voltage- and ligand-gated ion channels in cultured neurons of the rat inferior colliculus by lidocaine [Page 1409-1418]
Yu M, Chen L    
[ Abstract ][ Full text]


Cardiovascular and Pulmonary Pharmacology  

Endothelium-derived hyperpolarizing factor mediated relaxations in pig coronary arteries do not involve Gi/o proteins [Page 1419-1424]
Ng KFJ, Leung SWS, Man RYK, Vanhoutte PM  
[ Abstract ][ Full text]

Hypoxia confers protection against apoptosis via the PI3K/Akt pathway in endothelial progenitor cells [Page 1425-1431]
Dai T, Zheng H, Fu GS  
[ Abstract ][ Full text]

Acute pulmonary inflammation is inhibited in CXCR3 knockout mice after short-term cigarette smoke exposure [Page 1432-1439]
Nie L, Xiang RL, Liu Y, Zhou WX, Jiang L, Lu B, Pang BS, Cheng DY, Gao JM  
[ Abstract ][ Full text]


Anti-tumor Pharmacology  

Estrogen plays a critical role in AAV2-mediated gene transfer in ovarian cancer [Page 1440-1450]
Shi WF, Bartlett JS  
[ Abstract ][ Full text]

Over-expression of nm23-H1 in HeLa cells provides cells with higher resistance to oxidative stress possibly due to raising intracellular p53 and GPX1 [Page 1451-1458]
An R, Chu YL, Tian C, Dai XX, Chen JH, Shi Q, Han J, Dong XP
[ Abstract ][ Full text]

Suberoyl bis-hydroxamic acid induces p53-dependent apoptosis of MCF-7 breast cancer cells [Page 1459-1466]
Zhuang ZG, Fei F, Chen Y, Jin W  
[ Abstract ][ Full text]

Synergistic antitumoral activity and induction of apopto-sis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma [Page 1467-1477]
Mi JX, Wang GF, Wang HB, Sun XQ, Ni XY, Zhang XW, Tang JM, Yang DJ  
[ Abstract ][ Full text]


Immunopharmacology
 

Effect of plagiochin E, an antifungal macrocyclic bis(bi-benzyl), on cell wall chitin synthesis in Candida albicans [Page 1478-1485]
Wu XZ, Cheng AX, Sun LM, Lou HX  
[ Abstract ][ Full text]


Clinical Pharmacology  

Nosocomial colonization due to imipenem-resistant Pseudomonas aeruginosa epidemiologically linked to breast milk feeding in a neonatal intensive care unit [Page 1486-1492]
Mammina C, Di Carlo P, Cipolla D, Casuccio A, Tantillo M, Plano MRA, Mazzola A, Corsello G
[ Abstract ][ Full text]

Age-related changes of serum tartrate-resistant acid phosphatase 5b and the relationship with bone mineral density in Chinese women [Page 1493-1498]
Qin YJ, Zhang ZL, Zhang H, Hu WW, Liu YJ, Hu YQ, Li M, Gu JM, He JW
[ Abstract ][ Full text]


Pharmacokinetics
 

Quantitative determination of acetylshikonin in macaque monkey blood by LC-ESI-MS/MS after precolumn deri-va-tiza-tion with 2-mercaptoethanol and its application in pharmacokinetic study [Page 1499-1506]
Sun DX, Tian HF, Meng ZY, Du A, Yuan D, Gu RL, Wu ZN, Dou GF
[ Abstract ][ Full text]

Determination of the inhibitory potential of 6 fluoro-quino-lones on CYP1A2 and CYP2C9 in human liver microsomes [Page 1507-1514]
Zhang L, Wei MJ, Zhao CY, Qi HM
[ Abstract ][ Full text]


Drug Discovery
 

High-throughput screening assay for new ligands at human melatonin receptors [Page 1515-1521]
Yan JH, Su HR, Boutin JA, Renard MP, Wang MW
[ Abstract ][ Full text]

Optimal design and validation of antiviral siRNA for targeting hepatitis B virus [Page 1522-1528]
Fu J, Tang ZM, Gao X, Zhao F, Zhong H, Wen MR, Sun X, Song HF, Qian XH
[ Abstract ][ Full text]

Discovering novel 3-nitroquinolines as a new class of anticancer agents [Page 1529-1538]
Li HH, Huang H, Zhang XH, Luo XM, Lin LP, Jiang HL, Ding J, Chen KX, Liu H
[ Abstract ][ Full text]


Drug Discovery
 

Preparation of the phycoerythrin subunit liposome in a photodynamic experiment on liver cancer cells [Page 1539-1546]
Yan JH, Su HR, Boutin JA, Renard MP, Wang MW
[ Abstract ][ Full text]

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