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Acta Pharmacologica Sinica 2007 March; 28 (3): 334-338; doi: 10.1111/j.1745-7254.2007.00497.x |
| Original Article | [ Full text ] |
| Upregulation of Mark3 and Rpgrip1 mRNA expression by jujuboside A in mouse hippocampus1 |
Cheng WANG, Zi-li YOU2, Qing XIA, Tao XIONG, Yang XIA, De-zhong YAO School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China |
Methods: The spontaneous activity of mice was monitored, and the differential display polymerase chain reaction was adapted to screen differentially-expressed genes modulated by JuA in the mouse hippocampus.
Results: JuA significantly decreased the total activity intensity (P<0.01 vs control) at a dosage of 80 mg/kg, and the genes MAP/microtubule affinity-regulating kinase3 (Mark3) and retinitis pigmentosa GTPase regulator interacting protein1 (Rpgrip1) were upregulated by JuA in the mouse hippocampus.
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Keywords: jujuboside A; hippocampus; DD-PCR; Mark3; Rpgrip1 |
| 1 Project supported by a grant from the National Science Fund for Distinguished Young Scholars (No 30525030) and from Key Technologies R&D Program of Sichuan Province. |
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