Cover: Model for Ras signaling-regulated synaptic delivery of AMPA-R during long term potentiation (LTP). LTP-inducing stimuli activate NMDA receptors (NMDA-R) which results in the downstream activation of intracellular signaling pathways resulting in delivery of specific subtypes of AMPA receptors from stores in vesicles/endosomes (V/ES) to the cell membrane. The regulated trafficking of these specific AMPA receptor components (GluR1, GluR2L, GLuR2, GLuR3) and the role of slot proteins in this trafficking is covered in further detail in the article (page 928-936).

  Vol 28 Issue 7 (2007)  

REVIEWS

Cardiac sympathetic nerve terminal function in congestive heart failure. [Page 921-927]
Liang CS
[Extract][Full text]

Synaptic plasticity, AMPA-R trafficking, and Ras-MAPK signaling. [Page 928-936]
Gu Y, Stornetta RL
[Extract][Full text]

Ryanodine receptors as pharmacological targets for heart disease. [Page 937-944]
Santonastasi M, Wehrens XHT
[Extract][Full text]

ORIGINAL ARTICLES

Neuropharmacology

Cysteinyl leukotriene receptor 1 partially mediates brain cryoinjury in mice. [Page 945-952]
Ding Q, Fang SH, Zhou Y, Zhang LH, Zhang WP, Chen Z, Wei EQ
[Extract][Full text]

Effects of (-)-stepholidine on NMDA receptors: comparison with haloperidol and clozapine. [Page 953-958]
Gu WH, Yang S, Shi WX, Zhen XC, Jin GZ
[Extract][Full text]

Cardiovascular Pharmacology

Verapamil blocks HERG channel by the helix residue Y652 and F656 in the S6 transmembrane domain.[Page 959-967]
Duan JJ, Ma JH, Zhang PH, Wang XP, Zou AR, Tu DN
[Extract][Full text]

Receptor subtype involved in a1-adrenergic receptor-mediated Ca²⁺ signaling in cardiomyocytes.[Page 968-974]
Luo DL, Gao J, Fan LL, Tang Y, Zhang YY, Han QD
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Cellular and Molecular Pharmacology

Evaluation of hepatitis B virus replication and proteomic analysis of HepG2.2.15 cell line after cyclosporine A treatment.[Page 975-984]
Xie HY, Xia WL, Zhang CC, Wu LM, Ji HF, Cheng Y, Zhang SS
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Expression of vascular endothelial growth factor in cultured human dental follicle cells and its biological roles.[Page 985-993]
Chen XP, Qian H, Wu JJ, Ma XW, Gu ZX, Sun HY, Duan YZ, Jin ZL
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Detection and analysis of bovine foamy virus infection by an indicator cell line.[Page 994-1000]
He HQ, Ma XH, Liu B, Zhang XY, Chen WZ, Wang CX, Cheng SH
[Extract][Full text]

Gastrointestinal Pharmacology

Protective effects of heat shock protein70 induced by geranyl-geranylacetone in atrophic gastritis in rats.[Page 1001-1006]
Liu WL, Chen SJ, Chen Y, Sun LM, Zhang W, Zeng YM, Zhou TH, Si JM
[Extract][Full text]

Immunopharmacology

Molecular mechanisms of polypeptide from Chlamys farreri protecting HaCaT cells from apoptosis induced by UVA plus UVB.[Page 1007-1014]
Gao MQ, Guo SB, Chen XH, Du W, Wang CB
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Effect of Porphyromonas gingivalis PrtC on cytokine expression in ECV304 endothelial cells and its level in subgingival plaques from patients with chronic perio-dontitis. [Page 1015-1023]
Wu YM, Chen LL, Yan J, Zhuang CY, Gu ZY
[Extract][Full text]

Non-cytolytic antigen clearance in DNA-vaccinated mice with electroporation.[Page 1024-1030]
Peng JL, Zhao YG, Mai JH, Pang WK, Guo W, Chen GM, Mo GY, Rao GR, Xu YH
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Antitumor Pharmacology

Small interfering RNA of cyclooxygenase-2 induces growth inhibition and apoptosis independently of Bcl-2 in human myeloma RPMI8226 cells[Page 1031-1036]
Li QB, Chen ZC, You Y, Zou P
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Requirement of reactive oxygen species generation in apoptosis of leukemia cells induced by 2-methoxy-estradiol.[Page 1037-1044]
She MR, Li JG, Guo KY, Lin W, Du X, Niu XQ
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Dihydroartemisinin is an inhibitor of ovarian cancer cell growth.[Page 1045-1056]
Jiao Y, Ge CM, Meng QH, Cao JP, Tong J, Fan SJ
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P53-mediated cell cycle arrest and apoptosis through a caspase-3-independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells.[Page 1057-1066]
Cui Q, Yu JH, Wu JN, Tashiro SI, Onodera S, Minami M, Ikejima T
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Pharmacokinetics

Biotransformation of metoprolol by the fungus Cunning-hamella blakesleeana.[Page 1067-1074]
Ma B, Huang HH, Chen XY, Sun YM, Lin LH, Zhong DF
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Drug Design

Support vector machine for SAR/QSAR of phenethyl-amines.[Page 1075-1086]
Niu B, Lu WC, Yang SS, Cai YD, Li GZ
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ANNOUNCEMENTS 936,1044