Cover: Molecular mechanism responsible for the cardiac therapeutic effect of magnesium lithospermate B (MLB) extracted from Danshen (Salvia miltiorrhiza). The same signal transduction pathway (steps 1 to 5) down-stream from the inhibition of Na+,K+-ATPase by cardiac glycosides (eg, ouabain) was proposed for the therapeutic effect of MLB (page 609-615).

  Vol 28 Issue 5 (2007)  

REVIEW

JNK pathway: diseases and therapeutic potential. [Page 601-608]
Cui J, Zhang M, Zhang YQ, Xu ZH
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ORIGINAL ARTICLES

Neuropharmacology

Magnesium lithospermate B possesses inhibitory activity on Na⁺,K⁺-ATPase and neuroprotective effects against ischemic stroke. [Page 609-615]
Tzen JTC, Jinn TR, Chen YC, Li FY, Cheng FC, Shi LS, She HKH, Chen BCM, Hsieh V, Tu ML
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A cell-based model of a-synucleinopathy for screening compounds with therapeutic potential of Parkinson's disease. [Page 616-626]
Zhao DL, Zou LB, Zhou LF, Zhu P, Zhu HB
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l-Stepholidine increases the frequency of sEPSC via the activation of D₁ dopamine signaling pathway in rat prelimbic cortical neurons. [Page 627-633]
Gao M, Liu CL, Yang S, Zhen XC, Jin GZ
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Cardiovascular Pharmacology

Time-dependence of cardiomyocyte differentiation disturbed by peroxisome proliferator-activated receptor α inhibitor GW6471 in murine embryonic stem cells in vitro.[Page 634-642]
Ding L, Liang XG, Lou YJ
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Hypertonic and isotonic potassium solutions have different effects on vessel contractility resulting in differences in optimal resting tension in rat aorta.[Page 643-650]
Guan YF, Chen RH, Wang P, Qin Y, Su DF, Miao CY
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Prenatal exposure to lipopolysaccharide results in increases in blood pressure and body weight in rats.[Page 651-656]
Wei YL, Li XH, Zhou JZ
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Cellular and Molecular Pharmacology

Co-application of ricin A chain and a recombinant adeno-virus expressing ricin B chain as a novel approach for cancer therapy.[Page 657-662]
Wang HB, Xia F, Ge J, Yin J, Tan LS, Zhang PD, Zhong J
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Neocartilage formation from predifferentiated human adipose derived stem cells in vivo.[Page 663-671]
Jin XB, Sun YS, Zhang K, Wang J, Ju XD, Lou SQ
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Pulmonary Pharmacology

Nitrofen suppresses cell proliferation and promotes mitochondria-mediated apoptosis in type II pneumocytes.[Page 672-684]
Tong QS, Zheng LD, Tang ST, Jiang GS, Ruan QL, Zeng FQ, Dong JH
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Endocrine Pharmacology

Effects of gestrinone on uterine leiomyoma and expression of c-Src in a guinea pig model.[Page 685-694]
Zhu Y, Qiu XY, Wang L, Wu JH, Liu GM, He GL, Jiang XR, Sun ZY, Cao L
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Immunopharmacology

Cytotoxic T lymphocyte response induced by an improved synthetic lipopeptide vaccine against cervical cancer.[Page 695-702]
Xu DH, Zhou CH, Xia YP, Qiu ZY, Wu YZ, Jia ZC, Zhou W
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Effects of notoginosides on proliferation and upregulation of GR nuclear transcription factor in hematopoietic cells.[Page 703-711]
Gao RL, Chen XH, Lin XJ, Qian XD, Xu WH, Chong BH
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Antitumor Pharmacology

Bufalin induces apoptosis in human osteosarcoma U-2OS and U-2OS methotrexate300-resistant cell lines.[Page 712-720]
Yin JQ, Shen JN, Su WW, Wang J, Huang G, Jin S, Guo QC, Zou CY, Li HM, Li FB
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Pretreatment with insulin enhances anticancer functions of 5-fluorouracil in human esophageal and colonic cancer cells.[Page 721-730]
Zou K, Ju JH, Xie H
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Affinity of anticancer drug, daunomycin, to core histones in solution: comparison of free and cross-linked proteins.[Page 731-737]
Rabbani A, Abdosamadi S, Sari-Saraf N
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Pharmacokinetics

Pharmacokinetic-pharmacodynamic modeling of telmisartan using an indirect response model in spontaneously hypertensive rats.[Page 738-743]
Hao K, Chen YC, Cao YG, Yu D, Liu XQ, Wang GJ
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Pharmaceutics

Artificial pulmonary surfactant as a carrier for intra-tracheally instilled insulin.[Page 744-750]
Ji Y, Liu C, Pei YY
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ANNOUNCEMENTS 626, 720