Cover: Chemical signals generated by dietary phytochemicals/toxicants induce nuclear translocation of redox sensitive transcription factor Nrf2. Upon entering nucleus, Nrf2 recruits a dynamic machinery of nuclear co-regulators forming a multi-protein complex varied in the context of tissues specificity. This transcriptional complex modulates preventive/toxicologic genes expression through the Antioxidant Response Element (ARE). (page 459-472).

  Vol 28 Issue 4 (2007)  

REVIEW

Natural dietary anti-cancer chemopreventive compounds: redox-mediated differential signaling mechanisms in cyto- protection of normal cells versus cytotoxicity in tumor cells. [Page 459-472]
Nair S, Li W, Kong ANT
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ORIGINAL ARTICLES

Neuropharmacology

Clonidine attenuates morphine withdrawal and subsequent drug sensitization in rhesus monkeys. [Page 473-483]
Chen SQ, Zhai HF, Cui YY, Shi J, Le Foll B, Lu L
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Cardiovascular Pharmacology

Circadian expression of clock genes and angiotensin II type 1 receptors in suprachiasmatic nuclei of sinoaortic-denervated rats.[Page 484-492]
Li H, Sun NL, Wang J, Liu AJ, Su DF
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Adeno-associated virus vectors simultaneously encoding VEGF and angiopoietin-1 enhances neovasculariza-tion in ischemic rabbit hind-limbs.[Page 493-502]
Chen F, Tan Z, Dong CY, Chen X, Guo SF
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Inhibitory effects of coronary vasodilator papaverine on heterologously-expressed HERG currents in Xenopus oocytes.[Page 503-510]
Kim CS, Lee N, Son SJ, Lee KS, Kim HS, Kwak YG, Chae SW, Lee SD, Jeon BH, Park JB
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Effect of atorvastatin on non-ischemic heart failure and matrix metalloproteinase-2 and 9 in rats.[Page 511-517]
Cheng G, Xu G, Cai HW, Wang HH, Bao XF
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Pulmonary Pharmacology

(5R)-5-hydroxytriptolide (LLDT-8) protects against bleomycin-induced lung fibrosis in mice.[Page 518-525]
Ren YX, Zhou R, Tang W, Wang WH, Li YC, Yang YF, Zuo JP
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Molecular Pharmacology

A novel recombinant, VPAC2-selective agonist enhancing insulin release and glucose disposal.[Page 526-533]
Yu RJ, Tam NL, Gao Y, Zeng ZH, Zhou TH, Hong A
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Endocrine Pharmacology

Beneficial metabolic effects of nateglinide versus acarbose in patients with newly-diagnosed type 2 diabetes. [Page 534-539]
Gao HW, Xie C, Wang HN, Lin YJ, Hong TP
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Antitumor Pharmacology

Autophagy is involved in cytotoxic effects of crotoxin in human breast cancer cell line MCF-7 cells.[Page 540-548]
Yan CH, Yang YP, Qin ZH, Gu ZL, Reid P, Liang ZQ
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Embryo-chondrocyte expressed gene 1, downregulating hypoxia-inducible factor 1α, is another marker of lung tumor hypoxia.[Page 549-558]
Zhang L, Li QQ
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Antitumor activity of a novel bis-aziridinylnaphthoquinone (AZ4) mediating cell cycle arrest and apoptosis in non-small cell lung cancer cell line NCI-H460.[Page 559-566]
Shyu KG, Huang ST, Kuo HS, Cheng WP, Lin YL
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Gum mastic increases maspin expression in prostate cancer cells.[Page 567-572]
He ML, Chen WW, Zhang PJ, Jiang AL, Fan W, Yuan HQ, Liu WW, Zhang JY
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Pharmacokinetics

Effect of baicalin and berberine on transport of nimodipine on primary-cultured, rat brain microvascular endothelial cells.[Page 573-578]
Zhang DM, Liu HY, Xie L, Liu XD
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Clinical Pharmacology

Effect of MDR1 gene polymorphism on progression of end-stage renal disease.[Page 579-583]
Zhang WX, Chen B, Zhang W, Chen N, Yu ZC, Cai WM
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Pharmaceutics

Preparation of ion-activated in situ gel systems of scopolamine hydrobromide and evaluation of its antimotion sickness efficacy.[Page 584-590]
Cao SL, Zhang QZ, Jiang XG
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Prediction of human skin permeability using artificial neural network (ANN) modeling.[Page 591-600]
Chen LJ, Lian GP, Han LJ
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ANNOUNCEMENTS 492, 566