Cover: The figure generated by Pymol demonstrates the three-dimensional binding models of compounds 4b and 4d-h with PPARα The binding pocket is represented by hydropathicity surface and the transition from hydrophilicity to hydrophobicity takes place as the surface goes from blue to red (page 2040-2052).

  Vol 28 Issue 12 (2007)  

REVIEWS

Dual roles of NF-κB in cell survival and implications of NF-κB inhibitors in neuroprotective therapy. [Page 1859-1872]
Qin ZH, Tao LY, Chen X
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ORIGINAL ARTICLES

Neuropharmacology

Effects of GSM 1800 MHz on dendritic development of cultured hippocampal neurons. [Page 1873-1880]
Ning W, Xu SJ, Chiang H, Xu ZP, Zhou SY, Yang W, Luo JH
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Neuroprotection by sodium ferulate against glutamate-induced apoptosis is mediated by ERK and PI3 kinase pathways. [Page 1881-1890]
Jin Y, Yan EZ, Fan Y, Guo XL, Zhao YJ, Zong ZH, Liu Z
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Electrophysiological actions of cyclosporin A and tacrolimus on rat hippocampal CA1 pyramidal neurons. [Page 1891-1897]
Yu Y, Chen XQ, Cui YY, Hu GY
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Cardiovascular Pharmacology

Intramuscular delivery of rAAV-mediated kallikrein gene reduces hypertension and prevents cardiovascular injuries in model rats. [Page 1898-1906]
Wang T, Hou LB, Liu ZJ, Wang Y, Chen CL, Xiao X, Wang DW
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Heat shock protein 90 acts as a molecular chaperone in late-phase activation of extracellular signal-regulated kinase 1/2 stimulated by oxidative stress in vascular smooth muscle cells. [Page 1907-1913]
Liu DH, Yuan HY, Cao CY, Gao ZP, Zhu BY, Huang HL, Liao DF
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Antioxidant properties of berberine on cultured rabbit corpus cavernosum smooth muscle cells injured by hydrogen peroxide. [Page 1914-1918]
Tan Y, Tang Q, Hu BR, Xiang JZ
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Pulmonary Pharmacology

Triptolide inhibits NF-κB activation and reduces injury of donor lung induced by ischemia/reperfusion. [Page 1919-1923]
He JK, Yu SD, Zhu HJ, Wu JC, Qin ZH
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Liver Pharmacology

Differentiation of embryoid-body cells derived from embryonic stem cells into hepatocytes in alginate microbeads in vitro. [Page 1924-1930]
Fang S, Qiu YD, Mao L, Shi XL, Yu DC, Ding YT
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Selective enrichment of hepatocytes from mouse embryonic stem cells with a culture system containing cholestatic serum.[Page 1931-1937]
Min J, Shang CZ, Chen YJ, Zhang L, Liu L, Deng XG, Yang M, Chen DP, Cao J, Song EW, Chen JS
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Endocrine Pharmacology

Fluvastatin inhibits activation of JAK and STAT proteins in diabetic rat glomeruli and mesangial cells under high glucose conditions. [Page 1938-1946]
Shi YH, Zhao S, Wang C, Li Y, Duan HJ
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Astragalus polysaccharide reduces hepatic endoplasmic reticulum stress and restores glucose homeostasis in a diabetic KKAy mouse model.[Page 1947-1956]
Mao XQ, Wu Y, Wu K, Liu M, Zhang JF, Zou F, Ou-Yang JP
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Antitumor Pharmacology

Growth suppression and radiosensitivity increase by HMGB1 in breast cancer.[Page 1957-1967]
Jiao Y, Wang HC, Fan SJ
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Silencing livin gene by siRNA leads to apoptosis induction, cell cycle arrest, and proliferation inhibition in malignant melanoma LiBr cells.[Page 1968-1974]
Wang H, Tan SS, Wang XY, Liu DH, Yu CS, Bai ZL, He DL, Zhao J
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Pseudolaric acid B induces apoptosis, senescence, and mitotic arrest in human breast cancer MCF-7.[Page 1975-1983]
Yu JH, Cui Q, Jiang YY, Yang W, Tashiro SI, Onodera S, Ikejima T
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AICAR inhibits proliferation and induced S-phase arrest, and promotes apoptosis in CaSki cells.[Page 1984-1990]
Guan TJ, Qin FJ, Du JH, Geng L, Zhang YY, Li M
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Anticancer effect of aloe-emodin on cervical cancer cells involves G₂/M arrest and induction of differentiation.[Page 1991-1995]
Guo JM, Xiao BX, Liu Q, Zhang S, Liu DH, Gong ZH
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Enhanced sensitivity of hepatocellular carcinoma cells to chemotherapy with a Smac-armed oncolytic adenovirus.[Page 1996-2004]
Pan QW, Zhong SY, Liu BS, Liu J, Cai R, Wang YG, Liu XY, Qian C
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Detecting robust gene signature through integrated analysis of multiple types of high-throughput data in liver cancer.[Page 2005-2010]
Zhang XY, Li TT, Liu XJ
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Establishment of multiplexed, microsphere-based flow cytometric assay for multiple human tumor markers. [Page 2011-2018]
Sun K, Wang Q, Huang XH, Zhen MC, Li W, Zhang LJ
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Specific targeting of gliomas with multifunctional superpara-magnetic iron oxide nanoparticle optical and magnetic resonance imaging contrast agents.[Page 2019-2026]
Meng XX, Wan JQ, Jing M, Zhao SG, Cai W, Liu EZ
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Drug Screening

Novel selective inhibitors of hydroxyxanthone derivatives for human cyclooxygenase-2.[Page 2027-2032]
Chen YC, Chen KT
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Rhodanine derivatives as novel peroxisome proliferator-activated receptor γ agonists.[Page 2033-2039]
Liu Q, Zhang YY, Lu HL, Li QY, Zhou CH, Wang MW
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Drug Design

Structure-based drug design of a novel family of chalcones as PPARα agonists: virtual screening, synthesis, and biological activities in vitro.[Page 2040-2052]
Li XH, Zou HJ, Wu AH, Ye YL, Shen JH
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Molecular docking and 3D-QSAR studies of 2-substituted 1-indanone derivatives as acetylcholinesterase inhibitors.[Page 2053-2063]
Shen LL, Liu GX, Tang Y
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INDEX 2064, 2069

ACKNOWLEDGEMENTS TO REVIEWERS 2075